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    Did you mean Epidermal Homeostasis?
    Glossary Epidermal Homeostasis

    balanced renewal of skin cells maintaining skin's protective function

    Epidermal homeostasis refers to the balanced state of the outermost layer of the skin, where old skin cells are continuously shed and replaced by new ones. This process ensures that the skin remains healthy, resilient, and capable of performing its protective functions. For professionals, it involves a complex interplay of cellular proliferation, differentiation, and apoptosis, regulated by various signaling pathways and environmental factors.

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    Research 30 of 1000+

    1. Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 7 citations
    2. SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation Cellular and Molecular Immunology · 2026
    3. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    4. Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases 2026
    5. Human epidermal resident memory T cells: beyond the dermal perspective Frontiers in Immunology · 2026
    6. IL-1 Receptor–Knockout Mice Develop Epidermal Cysts and Show an Altered Innate Immune Response after Exposure to UVB Radiation Journal of Investigative Dermatology · 2017 · 20 citations
    7. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    8. Eavesdropping on the conversation between immune cells and the skin epithelium International Immunology · 2019 · 10 citations
    9. “Structural imprinting” of the cutaneous immune effector function Tissue Barriers · 2020 · 4 citations
    10. Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1 Development · 2010 · 34 citations
    11. Iron Deficiency in Immune-Mediated Inflammatory Skin Diseases: A Missing Link Between Systemic Inflammation, Immunometabolism, and Disease Burden Cells · 2026
    12. 766 H3K9me3 methyltransferase SETDB1 controls retrotransposon silencing, DNA methylation, constitutive heterochromatin maintenance and 3D-chromatin structure in epidermal keratinocytes 2023
    13. 591 A New 3D Skin Model Containing Autologous Immune Cells Reconstructed by Tissue Engineering Journal of Investigative Dermatology · 2019
    14. Abstract 18: Targeted epidermal ablation of EGFR causes local and systemic inflammation Cancer Research · 2010 · 2 citations
    15. Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis 2013 · 51 citations
    16. Abstract 4385: Live-imaging the interface between homeostasis and cancer initiation Cancer research · 2016
    17. RANK as a therapeutic target in cancer ˜The œFEBS journal · 2016 · 50 citations
    18. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015 · 129 citations
    19. Keratinocyte biology and pathology Veterinary Dermatology · 2014 · 33 citations
    20. Temporal Dynamics of Endothelium After Radiation Injury Reveal a Transient Pro-Angiogenic Capillary Subpopulation Associated with Skin Repair International Journal of Molecular Sciences · 2026
    21. Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis The Journal of Cell Biology · 2013 · 1 citations
    22. 167 Epidermal GRK2 knockout triggers a hair loss phenotype with features resembling immune-mediated alopecias Journal of Investigative Dermatology · 2023
    23. Laminin α5 in the keratinocyte basement membrane is required for epidermal–dermal intercommunication Matrix Biology · 2016 · 57 citations
    24. Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis Journal of Investigative Dermatology · 2020 · 15 citations
    25. Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2024
    26. ZNF750 safeguards upper hair follicle homeostasis to prevent inflammatory skin disease Journal of Investigative Dermatology · 2026
    27. Group IID, IIE, IIF and III secreted phospholipase A2s Biochimica and biophysica acta. Molecular and cell biology of lipids · 2018 · 23 citations
    28. Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation Scientific Reports · 2017 · 27 citations
    29. CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways Cell Death and Disease · 2025
    30. The G-Protein Couple Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2024