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    Did you mean Epidermal Hyperplasia?
    Glossary Epidermal Hyperplasia

    abnormal increase in skin cell layers, causing thickened skin

    Epidermal Hyperplasia, also known as epidermal thickening, is a condition where the outer layer of the skin (epidermis) undergoes an abnormal increase in the number of cells, leading to a thicker skin layer. This can be a response to chronic irritation, inflammation, or certain skin disorders, and may present as rough, scaly patches on the skin. For professionals, it is important to note that this condition can be indicative of underlying issues such as psoriasis or chronic eczema.

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    Research 30 of 1000+

    1. Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia American Journal Of Pathology · 2008 · 100 citations
    2. Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells Molecular Carcinogenesis · 2007 · 31 citations
    3. Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin inflammation Experimental Dermatology · 2015 · 12 citations
    4. Depletion of <i>Gsdma1/2/3</i> alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR–Stat3/Akt pathway Journal of Molecular Cell Biology · 2023 · 6 citations
    5. Conditional epidermal expression of TGFβ1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia Proceedings of the National Academy of Sciences · 2001 · 103 citations
    6. Loss of epidermal PLCg1 induced sebaceous gland hyperplasia and sparse hair Journal of dermatological science · 2017
    7. The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia Journal of Investigative Dermatology · 1996 · 128 citations
    8. Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease Journal of Cell Science · 2008 · 85 citations
    9. Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis Proceedings of the National Academy of Sciences · 2017 · 59 citations
    10. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin Proceedings of the National Academy of Sciences · 2001 · 201 citations
    11. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice Oncogene · 1997 · 147 citations
    12. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017 · 72 citations
    13. The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles European Journal of Cell Biology · 2004 · 51 citations
    14. Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic mice The FASEB Journal · 2004 · 49 citations
    15. Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing theneu oncogene under the control of the bovine keratin 5 promoter Molecular Carcinogenesis · 1998 · 47 citations
    16. Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles. PubMed · 1998 · 35 citations
    17. Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor Toxicologic Pathology · 2008 · 21 citations
    18. Role of bulge epidermal stem cells and TSLP signaling in psoriasis EMBO molecular medicine · 2019 · 19 citations
    19. Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10. PubMed · 1994 · 13 citations
    20. Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin and the phorbol ester 12-<i>O</i>-tetradecanoylphorbol-13-acetate Carcinogenesis · 1987 · 12 citations
    21. Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis JCI Insight · 2025 · 1 citations
    22. SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation Cellular and Molecular Immunology · 2026
    23. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    24. 269 Down-regulatory role of cholecystokinin on psoriatic epidermal inflammation Journal of Investigative Dermatology · 2017
    25. Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis Cell death and differentiation · 2011 · 76 citations
    26. Upregulation of interfollicular epidermal and hair infundibulum β-catenin expression in Gsdma3 mutant mice Acta histochemica · 2012 · 11 citations
    27. Inducible cre-mediated N-ras activation and PTEN inactivation in transgenic mouse melanocytes requires keratinocyte hyperplasia to elicit a melanocyte pathology Enlighten: Publications (The University of Glasgow) · 2005
    28. Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development Oncogene · 1998 · 136 citations
    29. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled EMBO journal · 2002 · 127 citations
    30. Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. PubMed · 1997 · 107 citations