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    Glossary Epidermal Homeostasis

    balanced renewal of skin cells maintaining skin's protective function

    Epidermal homeostasis refers to the balanced state of the outermost layer of the skin, where old skin cells are continuously shed and replaced by new ones. This process ensures that the skin remains healthy, resilient, and capable of performing its protective functions. For professionals, it involves a complex interplay of cellular proliferation, differentiation, and apoptosis, regulated by various signaling pathways and environmental factors.

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    1. Epidermal homeostasis: a balancing act of stem cells in the skin Nature Reviews Molecular Cell Biology · 2009 · 1039 citations
    2. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    3. Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis Cell death and differentiation · 2011 · 76 citations
    4. Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis Proceedings of the National Academy of Sciences · 2017 · 59 citations
    5. Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity Nature Communications · 2019 · 38 citations
    6. The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling Frontiers in Cell and Developmental Biology · 2022 · 35 citations
    7. Activated Kras Alters Epidermal Homeostasis of Mouse Skin, Resulting in Redundant Skin and Defective Hair Cycling Journal of Investigative Dermatology · 2010 · 29 citations
    8. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    9. Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2007 · 19 citations
    10. Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs 2021 · 12 citations
    11. Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair International Journal of Molecular Sciences · 2015 · 10 citations
    12. Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia Histochemistry and Cell Biology · 2014 · 7 citations
    13. Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis JCI Insight · 2025 · 1 citations
    14. SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation Cellular and Molecular Immunology · 2026
    15. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis 2024
    16. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    17. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    18. Reviewer #3 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    19. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    20. Reviewer #2 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    21. Reviewer #4 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    22. Reviewer #1 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    23. eLife assessment: Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    24. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    25. 1336 The de novo DNA methyltransferase DNMT3A is required for epidermal homeostasis Journal of Investigative Dermatology · 2018
    26. Role of alkaline ceramidase 1 (Acer1) in regulating epidermal homeostasis and tumorigenesis Academic Commons (Stony Brook University) · 2017
    27. 855 Targeted deletion of crif1 in mouse skin epidermis impairs skin homeostasis Journal of Investigative Dermatology · 2017
    28. 852 Targeted deletion of crif1 in mouse skin epidermis impairs skin homeostasis Journal of Investigative Dermatology · 2017
    29. Author response: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ 2017
    30. Decision letter: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ 2016