research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis
Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
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research Whole-Genome Bisulfite Sequencing of Goat Skins Identifies Signatures Associated with Hair Cycling
DNA methylation changes are linked to hair growth cycles in goats.
research Changes in the Aging Dermal Hair Follicle Environment in Female Scalp
Aging causes changes in scalp cells that can negatively affect hair health.
research Regulation of the Wound Healing Response During Aging
Aging slows wound healing due to weaker cells and immune response.
research Human Scalp Skin as an Abundant and Accessible Source for Eccrine Sweat Gland Isolation and Organ Culture
Researchers found a new way to isolate sweat glands from the scalp for study and culture.
research Evolution of Trichocyte Keratins
Hair keratins evolved from ancient proteins, diversifying through gene changes, crucial for forming claws and later hair in mammals.
research Human Long-Term Deregulated Circadian Rhythm Alters Regenerative Properties of Skin and Hair Precursor Cells
Disrupted sleep patterns can harm skin and hair cell renewal, but melatonin might help.
research Sphingolipids of the Murine Hair
Murine hair has specific types of ceramides and glucosylceramides but lacks acylceramides.
research Forearm Hair Density And Risk Of Keratinocyte Cancers In Australian Adults
People with denser forearm hair have a higher risk of certain skin cancers.
research Investigation of the Molecular Identity of the Junctional Zone in Human Skin
GATA6 is important for maintaining and differentiating cells in a key area of human skin.
research A Hairy Situation: PADIs in Regeneration and Alopecia
Enzymes called PADIs play a key role in hair growth and loss.
research Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone
Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.
research Hair Follicle Stem Cell Progeny Heal Blisters While Pausing Skin Development
When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.
research Development and Homeostasis of the Skin Epidermis
The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
research The Rho GTPase Exchange Factor Vav2 Promotes Extensive Age-Dependent Rewiring of the Hair Follicle Stem Cell Transcriptome
Vav2 changes how hair follicle stem cells' genes work as they age, which might improve regeneration but also raise cancer risk.
research Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells
Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
research Polycomb Repressive Complex 2 in Adult Hair Follicle Stem Cells Is Dispensable for Hair Regeneration
Polycomb Repressive Complex 2 is not needed for hair regeneration.
research The Role of Integrin AlphaVbeta6 in Impaired Wound Healing and Hair Follicle Regeneration
Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.
research Stem Cells and the Circadian Clock
The circadian clock influences the behavior and regeneration of stem cells in the body.
research Tolerance of Spironolactone in Acne and Hirsutism Treatment
Most patients tolerated spironolactone for acne and hirsutism despite common side effects like menstrual changes and breast tenderness.
research A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth
Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.
research Stem Cell Heterogeneity and Plasticity in Epithelia
Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
research Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects Against Malignant Progression
Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.
research Screened of Long Non-Coding RNA Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep
Long non-coding RNAs help regulate wool fineness in Gansu alpine fine-wool sheep.
research Evaluation of Dermatologic Life Quality Among Cleanroom Workers in a Secondary Battery Factory
Cleanroom workers in a battery factory have worse skin and eye conditions due to the very dry environment.
research Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle
Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.
research Seaweeds as Source of Bioactive Substances and Skin Care Therapy: Cosmeceuticals, Algotherapy, and Thalassotherapy
Seaweeds have beneficial compounds for skin care, including anti-aging and protective effects.
research In Silico Analysis of the Age-Dependent Evolution of the Transcriptome of Mouse Skin Stem Cells
The research found that the gene activity in mouse skin stem cells changes significantly as they age.
research Clinical and Biological Impact of the Exposome on the Skin
Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.
research Aging and Colony-Forming Efficiency of Human Hair Follicle Keratinocytes
Aging reduces the ability of human hair follicle cells to form new cell colonies.