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This study identified a novel microscopic "arrow sign" in hair root sheaths of patients on EGFR inhibitors, potentially aiding in diagnosing related hair changes and differentiating from fungal infections.

This case study suggests that overgrowth of microorganisms with hyperkeratosis may contribute to the induction of lichen planopilaris by disrupting the immune privilege of hair follicles.

This study found that neutrophil-rich hair follicle inflammation caused by a monoclonal antibody targeting murine EGFR in mice involved TNFα and interleukin-1, suggesting these cytokines play a role in EGFR antibody-induced rashes in cancer patients.

This study in mice found that a monoclonal antibody targeting EGFR resulted in skin inflammation mediated by TNFα, suggesting potential pathways for addressing EGFR antibody-induced skin rash in cancer patients.

In this mouse study, the researchers found that the monoclonal antibody ME1 causes hair follicle inflammation by up-regulating TNFα, which can be reduced by TNFα and interleukin-1 inhibitors.

This study found no significant differences in phosphatide distribution between normal and cancerous mouse epidermis during different stages of growth, despite variations in total phosphatide levels.

This study found that a high dose of epidermal growth factor induced hair loss in sheep by causing apoptosis in anagen hair and transitioning the hair cycle to catagen.

This study observed that areola formation in mice requires exposure to pregnancy hormones and mechanical strain, beyond individual stimuli like hormonal milieu or strain alone.

This study found distinct skin surface changes, including faint mosaic melanoderma and atypical scaliness, on long-standing sun-exposed balding scalps that may be associated with actinic field carcinogenesis.

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

In this study, researchers found that glycan profiles in epidermal stem cells differed between young and old mice, suggesting these changes may serve as molecular markers for aging.

This study examined prenatal and postnatal development of rat skin, observing marked changes in epidermal thickness and collagen fiber distribution as the rats aged.

This study found that Lgr5 and Lgr6 stem cells both activated wound-healing genes, but only Lgr5 stem cells changed their identity to contribute to new skin formation during wound repair.

This review discusses the classification, pathogenesis, and management of skin, hair, nail, and mucosal changes due to EGFR inhibitors, emphasizing the importance of informing patients to improve therapy compliance.

This study reports that Iressa, an anti-cancer agent, commonly causes acneiform eruptions and xerosis as cutaneous side effects, similar to other agents targeting epidermal growth factor receptors.

In this study, application of salicylic acid solution on mouse skin showed histologic changes without causing wounds or inflammation, observed immediately and up to 48 hours after treatment.

This study found that transgenic mice expressing human keratin K8 in the epidermis showed increased progression of skin lesions toward malignancy, suggesting a role for K8 in the development of invasive skin cancer.

This study reported that deleting the MED1 subunit from the MED complex in keratinocytes resulted in disrupted hair differentiation and cycling, leading to hair loss in mice.

This study found that transgenic mice overexpressing human ATF3 showed hyperplastic and dysplastic changes in epithelial tissues, with a high incidence of oral cancer, suggesting potential oncogenic properties of ATF3.

This report presents the Taiwanese Dermatological Association's 2016 consensus on defining and managing skin toxicities from EGFR-TKI treatments, providing comprehensive guidelines for clinicians in Taiwan.

This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.

This study in SPF lambs found that primary and secondary orf virus infections trigger similar skin responses, but the primary infection caused a more severe and prolonged reaction.

This report details a case of a 43-year-old woman developing yellowish papular eruptions alongside typical acneiform skin reactions on her cheeks and chest following a switch from cetuximab to panitumumab treatment.

This study found that while the combination of oral propranolol and intradermal injections in guinea pigs led to psoriasiform changes, it did not fully mimic psoriasis.

This review highlights advances in understanding inflammatory memory in epidermal stem cells, focusing on their capacity to remember prior inflammatory responses and respond more quickly to future stimuli, potentially aiding strategies against skin-related diseases.

In this study of sheep across various breeds and ages, researchers found that Trichophyton mentagrophytes caused severe dermatophytosis, especially affecting young Shahbadi sheep during winter, leading to notable anemia and skin lesions.

This study suggests that the synthetic peptide SPIKENET (SPK) may protect against long-term skin alterations in mice following coronavirus infection, offering potential therapeutic intervention for similar effects in humans post-COVID-19.

This study on female Wistar rats with stress-induced alopecia found that a modified diet rich in antioxidants and nutrients reduced dystrophic skin changes and preserved the functional activity of hair follicles, suggesting dietary approaches may support hair restoration under chronic stress conditions.

This study in a Lithuanian veterinary clinic observed diverse histomorphological skin changes in alopecic dogs caused by various rare diseases, including hyperkeratinization and pigmentation disorders.

This article discusses the clinical manifestations and management strategies of skin side effects from epidermal growth factor receptor inhibitors, but reports no new clinical findings.