research Regulation of the Wound Healing Response During Aging
Aging slows wound healing due to weaker cells and immune response.
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research Skin Structure
Human skin has multiple layers and functions, with key roles in protection, temperature control, and appearance.
research Editors' Picks
Scientists found gene mutations that affect hair loss, skin stem cells, and skin disorders, and identified drugs that may help treat blood vessel and skin conditions.
research Impairment of Hair-Inducing Capacity of 3D-Cultured Human Dermal Papilla Cells by the Ablation of STAT5
Removing STAT5 from 3D-cultured human skin cells reduces their ability to grow hair.
research Montagna Symposium 2015: Harnessing Stem Cells to Reveal Novel Skin Biology and Disease Treatments
The symposium showed that stem cells are key for understanding and treating skin diseases and for developing new skin models and therapies.
research Concise Review: Human Dermis as an Autologous Source of Stem Cells for Tissue Engineering and Regenerative Medicine
Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
research Role of Vitamin D and Calcium Signaling in Epidermal Wound Healing
Vitamin D and calcium are important for quick and effective skin wound healing.
research Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls
Hair growth environment recreated with challenges; stem cells make successful skin organoids.
research Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair
The document concludes that understanding how adult stem and progenitor cells move is crucial for tissue repair and developing cell therapies.
research Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle
Ephrins slow down skin and hair follicle cell growth.
research Functional Hair Follicle Regeneration: An Updated Review
Hair follicle regeneration possible, more research needed.
research Modulating the Stem Cell Niche for Tissue Regeneration
Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.
research Multipotent Nestin-Positive Stem Cells Reside in the Stroma of Human Eccrine and Apocrine Sweat Glands and Can Be Propagated Robustly In Vitro
Human sweat glands have a type of stem cell that can grow well and turn into different cell types.
research Functional Analysis of the PIP5K1A Gene in Liaoning Cashmere Goats: An Investigation Based on Bioinformatics, Tissue Localization, and Biological Functions
The PIP5K1A gene helps cashmere growth in goats by promoting cell proliferation, and melatonin boosts its expression.
research YAP And TAZ Are Essential For Basal And Squamous Cell Carcinoma Initiation
YAP and TAZ proteins are necessary for the development of two types of skin cancer.
research WNT10A Mutation Causes Ectodermal Dysplasia by Impairing Progenitor Cell Proliferation and KLF4-Mediated Differentiation
A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.
research Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives
Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.
research Defining the Transcriptional Signature of Esophageal-to-Skin Lineage Conversion
Adult esophageal cells can start to become like skin cells, with a key pathway influencing this change.
research Dormancy in the Stem Cell Niche
Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.
research Targeting the Wnt Pathways for Therapies
Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.
research Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing
Tiny vesicles from stem cells could be a new treatment for healing wounds.
research Circadian Clock-Mediated Control of Stem Cell Division and Differentiation: Beyond Night and Day
The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.
research Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia
Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.
research The Harmonies Played by TGF-β in Stem Cell Biology
TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.
research The Developing Immune Network in Human Prenatal Skin
Human prenatal skin develops an immune network early on that helps with skin formation and healing without scarring.
research Distinct Mechanisms for Sebaceous Gland Self-Renewal and Regeneration Provide Durability in Response to Injury
Sebaceous glands can heal and regenerate after injury using their own stem cells and help from hair follicle cells.
research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State
Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
research Metabolic Regulation of Stem Cells in Aging
Eating less can improve stem cell function and increase lifespan.
research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
research Investigation of the Molecular Identity of the Junctional Zone in Human Skin
GATA6 is important for maintaining and differentiating cells in a key area of human skin.