67 citations
,
August 2007 in “American Journal of Pathology” This study found that overexpression of the mineralocorticoid receptor in a mouse model led to premature epidermal barrier development, keratinocyte apoptosis, and postnatal alopecia, indicating new roles for MR signaling in skin physiology.
23 citations
,
July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that follicular stem cells in hair follicles are more sensitive to the antiproliferative effects of glucocorticoids compared to basal keratinocytes due to incomplete desensitization.
February 2024 in “Australasian journal of dermatology” This study found that in atrophic acne scars, inflammation infiltrates the pilosebaceous unit over time, affecting resident stem cells and hindering the normal regeneration of the epidermis and adnexal structures, leading to scarring.
2 citations
,
August 2016 in “Journal of Investigative Dermatology” August 2007 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This review discusses the effects of mineralocorticoid receptor overexpression in mice skin, reporting no new data but highlighting its link to epidermal atrophy, early barrier formation, eye issues, and hair loss.
135 citations
,
December 2006 in “PLoS Medicine” This study suggests that intermediate-size hyaluronate fragments may enhance keratinocyte proliferation and improve skin thickness in atrophic conditions through a CD44-dependent mechanism.
134 citations
,
January 2011 in “Development” This study found that disrupting Adam10 in the epidermis led to severe skin and multi-organ abnormalities, implicating Adam10 as crucial for proper Notch signaling and skin maintenance.
19 citations
,
September 2019 in “PLOS genetics” This study found that telomere shortening disrupts BMP/pSmad/P63 signaling, leading to skin atrophy via Follistatin up-regulation, and suggests potential therapeutic targets.
99 citations
,
October 2008 in “Journal of Investigative Dermatology” This study identified genetic mutations linked to congenital ichthyosis in families from the UAE and Turkey, revealing a connection between keratinization disorders and impaired filaggrin processing.
9 citations
,
July 2010 in “British Journal of Dermatology” This article reports on lentiginosis observed within plaques of linear atrophoderma of Moulin and discusses its potential classification as a twin-spotting phenomenon but provides no new clinical research results.
2 citations
,
November 2007 in “Journal of Investigative Dermatology” This study found that bulge keratinocytes in mice develop resistance to glucocorticoid treatment more slowly than interfollicular keratinocytes and do not significantly aid in repairing glucocorticoid-induced skin atrophy within five days.
April 2016 in “Journal of Clinical Research in Dermatology” This report describes a case of sclero-atrophy localized to the frontal scalp following an injection of botulinum toxin type A, which has not been previously documented in the literature.
57 citations
,
January 2004 in “Journal of Radiation Research” This study found that zinc supplementation reduced the severity and delayed the onset of radiation-induced skin injury in rats, with the greatest protection observed at a dose of 10 mg/kg/day.
36 citations
,
September 1999 in “Toxicologic pathology” This study suggests that hairless dogs' skin shows sensitivity to topical corticosteroids, highlighting their potential as a model for studying the efficacy and adverse effects of these treatments on skin.
15 citations
,
December 2011 in “Journal of the European Academy of Dermatology and Venereology” In this study, severe diffuse hair loss in patients with systemic lupus erythematosus was associated with distinct clinical, dermoscopic, and histopathological features, which improved alongside treatment of the underlying condition.
8 citations
,
February 2006 in “Journal of the European Academy of Dermatology and Venereology” This study found that growth hormone significantly reduced radiation-induced skin damage in rats compared to radiation alone, suggesting potential for mitigating such effects in cancer patients.
7 citations
,
October 2015 in “Experimental dermatology” This study found that topical MR blockers alongside glucocorticoids may limit glucocorticoid-induced skin atrophy, suggesting MR's significant role in skin-related endocrinology.
6 citations
,
March 2011 in “Experimental Dermatology” This study found that an imbalance of selenium in a C57BL/6 mouse model led to hair loss with color change and was linked with changes in hair follicle apoptosis markers.
5 citations
,
July 2013 in “Our Dermatology Online” This study found that lichen planopilaris was the most common variant of cicatricial alopecia among patients, with perifollicular fibrosis being a prevalent histopathological feature.
5 citations
,
August 2001 in “International Journal of Dermatology” This case study reports a 20-year-old laborer's progressive hair loss with scalp and body lesions, diagnosed as lichen planopilaris, leading to scarring alopecia resembling male-pattern baldness.
4 citations
,
January 2009 in “Acta agriculturae Serbica” This study observed that both excessive and deficient selenium levels in a C57BL/6 mouse model were associated with hair loss and changes in hair follicles, likely due to alterations in the hair follicle cycle and increased apoptosis.
2 citations
,
March 2019 in “Veterinary dermatology” The authors concluded that thymoma-associated paraneoplastic syndrome in cats may manifest as noninflammatory alopecia instead of exfoliative dermatitis, and should be considered when diagnosing multifocal noninflammatory alopecia.
2 citations
,
January 2017 in “International Journal of Trichology” This case report describes the trichoscopic and histological features observed in a 7-year-old boy with morphea en coup de sabre and details the positive response to systemic immunosuppressive therapy.
2 citations
,
June 2012 in “Dermatologica Sinica” Dermoscopy is useful for diagnosing and monitoring discoid lupus erythematosus by showing specific skin patterns.
1 citations
,
July 2013 in “Journal of Pakistan Association of Dermatologists” This study found that the most common form of cicatricial alopecia was lichen planopilaris (27.5%), followed by discoid lupus erythematosus (25%), while perifollicular fibrosis was the prevalent histopathological feature (65%).
June 2026 in “Reports of Morphology” This study on female Wistar rats with stress-induced alopecia found that a modified diet rich in antioxidants and nutrients reduced dystrophic skin changes and preserved the functional activity of hair follicles, suggesting dietary approaches may support hair restoration under chronic stress conditions.
January 2024 in “Revista Dermatológica Centro Uraga” This case report describes a 68-year-old woman diagnosed with chronic cutaneous lupus, characterized by irregular plaques with distinct pigmentation and scarring alopecia, confirmed through histopathology revealing specific skin changes.
August 2023 in “Clinical Infectious Diseases” This study presented the case of an 81-year-old woman with 1-year history of scalp erosions and pustules, initially suspected to be infectious, but skin biopsy revealed impetiginized scale-crust, epidermal atrophy, dermal fibrosis, and mixed inflammatory infiltrate, leading to scarring alopecia.
March 2023 in “Nigerian Journal of Clinical Practice” This study found that SLE patients with hair loss exhibited significant differences in the size and number of sebaceous glands compared to those without hair loss, but showed no histopathological differences between affected and unaffected scalp areas.
January 1999 in “Journal of the European Academy of Dermatology and Venereology” RAPK is a rare skin disorder with pigmented spots, mainly on hands and feet, starting in youth.