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    Glossary Epidermal Atrophy

    thinning of outer skin layer, making it fragile

    Epidermal atrophy refers to the thinning of the outermost layer of the skin, known as the epidermis. This condition can result in the skin becoming more fragile, less elastic, and more prone to injuries and infections. It is often associated with aging, prolonged use of topical corticosteroids, or certain medical conditions like chronic dermatitis.

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    1. Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia American Journal of Pathology · 2007 · 67 citations
    2. Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy 2007 · 23 citations
    3. Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars Australasian journal of dermatology · 2024
    4. 575 Senescent atrophic epidermis retains Lrig1+ stem cells and loses Wnt signaling, a phenotype shared with CD44KO mice Journal of Investigative Dermatology · 2016 · 2 citations
    5. Faculty Opinions recommendation of Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2007
    6. Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism PLoS Medicine · 2006 · 135 citations
    7. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling Development · 2011 · 134 citations
    8. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    9. Ichthyosis, Follicular Atrophoderma, and Hypotrichosis Caused by Mutations in ST14 Is Associated with Impaired Profilaggrin Processing Journal of Investigative Dermatology · 2008 · 99 citations
    10. Lentiginosis within plaques of linear atrophoderma of Moulin: a twin-spotting phenomenon? British Journal of Dermatology · 2010 · 9 citations
    11. Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide Journal of Investigative Dermatology · 2007 · 2 citations
    12. Sclero-Atrophic Reaction after Botulinum Toxin Injection Journal of Clinical Research in Dermatology · 2016
    13. The Effect of Zinc Sulphate in The Prevention of Radiation-induced Dermatitis Journal of Radiation Research · 2004 · 57 citations
    14. Dorsal Skin Reactions of Hairless Dogs to Topical Treatment with Corticosteroids Toxicologic pathology · 1999 · 36 citations
    15. Severe diffuse non-scarring hair loss in systemic lupus erythematosus - clinical and histopathological analysis of four cases Journal of the European Academy of Dermatology and Venereology · 2011 · 15 citations
    16. Is growth hormone a radioprotective agent? Journal of the European Academy of Dermatology and Venereology · 2006 · 8 citations
    17. A novel actor in skin biology: the mineralocorticoid receptor Experimental dermatology · 2015 · 7 citations
    18. Changes in murine hair with dietary selenium excess or deficiency Experimental Dermatology · 2011 · 6 citations
    19. A clinical and histopathological study of cicatricial alopecia Our Dermatology Online · 2013 · 5 citations
    20. Lichen planopilaris International Journal of Dermatology · 2001 · 5 citations
    21. Occurrence of raspberry gall midge Lasioptera rubi Schrank (Diptera, Cecidomyiidae) in some raspberry cultivars. Acta agriculturae Serbica · 2009 · 4 citations
    22. A previously undescribed cutaneous paraneoplastic syndrome in a cat with thymoma Veterinary dermatology · 2019 · 2 citations
    23. Linear morphea alopecia: New trichoscopy findings International Journal of Trichology · 2017 · 2 citations
    24. Dermoscopic features of discoid lupus erythematosus Dermatologica Sinica · 2012 · 2 citations
    25. A clinical and histopathological study of cicatricial alopecia Journal of Pakistan Association of Dermatologists · 2013 · 1 citations
    26. Morphological changes in the skin in a rat model of stress-induced alopecia and their correction with nutrients Reports of Morphology · 2026
    27. Lupus cutáneo crónico Revista Dermatológica Centro Uraga · 2024
    28. An 81-Year-Old Woman With Erosions and Pustules Affecting Her Scalp Clinical Infectious Diseases · 2023
    29. Comparative histopathological analyses of non-scarring alopecia in systemic lupus erythematosus patients in Lagos Nigeria Nigerian Journal of Clinical Practice · 2023
    30. Correspondence Journal of the European Academy of Dermatology and Venereology · 1999