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This review highlights recent advancements in the engineering of skin organoids using hydrogels, which improve their structural and functional fidelity by supporting the architecture and integration of vascular and neural components, promising to enhance regenerative medicine, drug discovery, and complex skin disorder studies.

In this study, researchers identified a new dominant mutation in Hairless mice, called Pied, resulting from a deletion in the Adam10 gene, which causes freckle-like skin pigmentation by inhibiting melanocyte expansion.

This study demonstrates a varied distribution of keratins in the epidermis of the Malayan pangolin, suggesting evolutionary adaptations related to their distinctive scales.

This study reports the successful differentiation of mouse induced pluripotent stem cells into keratinocytes that can regenerate skin and its structures in an in vivo environment.

This study observed that earlier-passage keratinocyte cultures led to superior hair follicle neogenesis in dermal-epidermal composites grafted onto immunodeficient mice, suggesting their potential utility in studying human hair follicle development.

This study mapped gene expression in different skin structures of dogs, finding similarities to humans that support using dogs as models for human skin diseases.

The document concludes that hair biology is complex and there are still unanswered questions about hair loss and follicle changes.

This study successfully developed 3D hair follicle organoids from neonatal mouse epidermal and dermal cells, showing structural and molecular resemblance to native anagen hair follicles.

This study developed an in vitro artificial hair germ model using dermal papilla cells and skin keratinocytes to explore early stages of hair follicle regeneration.

This study demonstrates that hair follicle bulge stem cells can transition into other stem cell compartments, indicating their role in maintaining both hair follicles and sebaceous glands.

This review discusses the roles of Wnt signaling in skin organogenesis and related processes but reports no new experimental results, highlighting areas for future research.

This research reports that the polyG fragment within the Hoxc13 protein alters its gene regulatory functions, which could have influenced mammalian hair evolution by affecting pathways related to hair follicle development.

This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.

This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.

This review examines the differentiation potential of epithelial cells from various sources in hair follicle formation, concluding that complex interactions are required for hair-specific characteristics, which were achieved in vivo but not in vitro.

This study reports that transplantation and in vivo reprogramming using specific reprogrammed cell types can generate skin appendage-like structures in adult mice, suggesting potential therapeutic avenues for skin regeneration and disorders.

This chapter reviews skin components, wound healing mechanisms, and the potential of biomaterials to enhance skin repair and regeneration, without offering new experimental results.

This article explains the structure and multifunctional roles of the human skin, including its protective, regulatory, and sensory functions, but does not report new research findings.

This review discusses strategies and advances in bioprinting for skin wound healing, concluding that bioprinting could offer promising solutions for skin regeneration despite existing challenges.

This study suggests that wounding skin in adult mice can trigger new hair follicle formation, indicating mammalian skin may have greater regenerative capacity than previously thought.

Cathepsin L deficiency causes hair and skin issues in mice.

Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.

This study reports that EGF at specific concentrations promotes the proliferation and migration of hair follicle ORS cells by activating the Wnt/β-catenin signaling pathway in vitro.

This study introduced the concept of spatiotemporal clocks to understand how different phases of mammalian wound healing are coordinated, with a focus on the spatial domains and oscillatory molecular signals involved, while highlighting the potential for regenerative therapeutic strategies.

This review highlights the multifaceted roles of hair follicles in skin health, emphasizing their contribution to skin tumorigenesis, homeostasis, and wound healing, and how dysregulation in associated pathways like Wnt, Hedgehog, and Notch may contribute to skin cancer development.

This study observed that IGF-1R expression significantly decreased in basal keratinocytes of sacrococcygeal pilonidal sinus tissues, suggesting a potential role in its etiology, although further data are needed to evaluate its treatment implications.

In this study, AMACO was found to be non-essential for the formation or function of anchoring cords in mice, despite its presence in the structure.

In this study, the researchers developed a new protocol using human-induced pluripotent stem cells to efficiently create skin hair follicle organoids, which may aid in optimizing hair follicle growth and exploring treatments for alopecia.

This review examines the origins and mechanisms of tumor initiation in common skin cancers, but does not present new experimental findings; it emphasizes the need for further research on cancer stem cells.

This review discusses the use of lipid nanoparticles for topical and transdermal delivery of pharmaceuticals and cosmeceuticals and reports no new clinical results.