5 citations
,
January 2021 in “Frontiers in cell and developmental biology” This paper discusses the multipotency of cyst cells and proposes that understanding molecular circuits in cyst formation could enable engineering of desired stem cell culture phenotypes, but reports no new experimental outcomes.
1 citations
,
April 2018 in “Journal of Investigative Dermatology” This study found that Polycomb repressive complex 1 is crucial for skin development and stem cell specification, influencing gene activity beyond its known repressor functions.
39 citations
,
April 1992 in “Development” In this study, researchers detailed how hair follicles regenerate after microsurgical amputation, observing a wound reaction involving dynamic dermal-epidermal interactions and changes in extracellular matrix components.
April 2018 in “Journal of Investigative Dermatology” This study found that kaempferol increased the proliferation potential of basal epidermal cells in three-dimensional skin models by enhancing integrin expression and altering cell morphology.
April 2018 in “Journal of Investigative Dermatology” This study found that treating human dermal fibroblast cells with ginsenoside Rd increased the expression of mRNA associated with the dermal-epidermal junction, suggesting potential as an anti-aging cosmetic ingredient.
September 2022 in “Skin appendage disorders” This article explores potential risk factors for central centrifugal cicatricial alopecia and suggests that seborrheic dermatitis may play a role in its development, but it reports no new scientific findings.
April 2018 in “Journal of Investigative Dermatology” This study found that a water-soluble peptide from chicken egg yolk, named Hair Growth Peptide, improved hair growth in mice and female pattern hair loss through increased IGF-1 and VEGF production.
40 citations
,
June 2013 in “Molecular Pharmaceutics” This study demonstrates that transfected epidermal stem cells using a novel 3D transfection system significantly enhanced wound healing and may serve as an effective therapeutic agent and gene delivery method for wound treatment.
36 citations
,
April 2013 in “Cell and Tissue Research” Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.
11 citations
,
June 2012 in “Acta histochemica” This study found that Gsdma3 mutations in mice led to thicker skin and longer hair infundibula, possibly by negatively regulating β-catenin expression in the epidermis.
107 citations
,
August 2012 in “Seminars in Cell & Developmental Biology” This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.
59 citations
,
March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This review examines the roles of Smad-4 and Smad-7 in hair follicle differentiation and development through BMP signaling and TGFβ/Activin/BMP pathway inhibition but reports no new experimental results.
29 citations
,
November 2011 in “Veterinary pathology” This study reports that eccrine sweat glands in mice predominantly develop on the footpads, offering a reference for skin research involving genetically engineered mice.
This study utilized a pigmented human epidermal equivalent model to incorporate melanocytes into the epidermis and found enhanced differentiation potential compared to conventional in vitro systems, reflecting in vivo cellular trajectories and highlighting melanocyte-to-keratinocyte communication pathways.
228 citations
,
September 2012 in “Trends in Neurosciences” This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.
149 citations
,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” This article provides contact information for Bruce A. Morgan and features no new research findings.
This study found that ocu-miR-205 affects signaling pathways, promoting the apoptosis of dermal papilla cells and influencing hair follicle density in Rex rabbits.
This study found that ocu-miR-205 promotes apoptosis in dermal papilla cells, alters hair follicle signaling pathways, and affects hair density in Rex rabbits.
1 citations
,
January 2019 in “The International Journal of Lower Extremity Wounds” This study demonstrated in rodent models that artificial dermal template treatment can induce full-thickness skin regrowth including skin epidermis and adnexa without the need for autologous skin grafts.
This study found that ocu-miR-205 promotes the apoptosis of dermal papilla cells and the transformation of hair follicles from growth to regression and resting phases in Rex rabbits.
April 2017 in “Journal of Investigative Dermatology” This study suggests that dermal Wnt/β-catenin activation timing is crucial for hair follicle initiation, with potential non-cell autonomous regulation of dermal condensate size.
32 citations
,
December 2014 in “Cold Spring Harbor Perspectives in Medicine” This article reviews the role of polarity proteins in epidermal morphogenesis and homeostasis and discusses how their alteration may contribute to skin disease, but reports no new experimental findings.
48 citations
,
August 2018 in “Nature Communications” This study found that JunB, a transcription factor, is crucial for maintaining epidermal-pilosebaceous stem cell homeostasis by regulating progenitor cell behavior and preventing sebaceous gland dysfunction.
103 citations
,
November 2014 in “Journal of Cell Biology” This study found that overexpression of miR-214 in keratinocytes inhibits hair follicle development and cycling by targeting β-catenin in the Wnt signaling pathway.
65 citations
,
June 2003 in “EMBO journal” This study reports that overexpressing the BMP antagonist noggin in mice inhibits eyelid opening by reducing apoptosis and delaying cell differentiation in the eyelid epithelium.
41 citations
,
June 2013 in “PLOS ONE” This study demonstrated that engineered skin substitutes using human keratinocytes and murine dermal papilla cells can develop pigmented hairs without sebaceous glands, suggesting separate pathways for hair development and eruption.
18 citations
,
January 2017 in “Postępy Dermatologii i Alergologii” This review discusses the adverse skin effects of EGFR inhibitors used in cancer treatment, exploring their mechanisms and offering strategies for prevention and management, but reports no new experimental findings.
6 citations
,
January 2016 in “Journal of Stem Cell Research & Therapy” This study found that suppressing Jagged1 in epidermal stem cells disrupted Notch signaling and resulted in poor-quality wound healing, suggesting a potential therapeutic target for improving wound repair.
8 citations
,
December 2017 in “Skin appendage disorders” This study observed that the genes WNT7A, CASP7, and TNF were overexpressed in early stages of androgenetic alopecia, suggesting involvement of the WNT pathway, apoptosis, and inflammation in the disorder's development.
5 citations
,
March 2020 in “Cell and Tissue Banking” This study found that injecting a mixture of epidermal stem cells and dermal papilla cells can induce hair follicle regeneration and well-ordered epidermis formation in mice.