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The document does not confirm if radical prostatectomy is the best treatment for locally advanced prostate cancer.

Herpes gestationis is linked to certain antigens, atopic eczema affects T cell populations and may be eased by breastfeeding, higher doses of anti-androgen treatment can improve androgenic alopecia, topical minoxidil increases hair thickness, long-term methotrexate therapy can cause liver fibrosis in psoriasis patients, and Lichen Sclerosus et Atrophicus patients aren't at higher risk for autoimmune disorders.

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Most people on isotretinoin had chapped lips, but only a few stopped the medicine due to side effects.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

Liposomes could improve how skin care products work but are costly and not very stable.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

The document concludes that diagnosing and treating Human African Trypanosomiasis is challenging, but new treatments like fexinidazole are promising.

Clomipramine may significantly reduce hair-pulling in Trichotillomania, but more research is needed on treatments and early onset cases.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Some birth control pills have a higher risk of blood clots than others.

SHBG may be a useful early indicator and treatment target for PCOS.

Certain hormone treatments can improve acne and related conditions in women.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

COVID-19 can cause skin issues like chilblains and rashes, which may help in early detection, especially in patients without other symptoms.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Some skin disorders might be linked to H. pylori infection, but more research is needed to confirm this.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

The document concludes that veterinary dermatologists need more experience and a better approach to treating skin diseases in nonhuman primates.