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This study found that EPHA4 and Ephrin A3 genes are differentially expressed during hair follicle development in fine-wool sheep, suggesting roles in follicle regeneration and density.

Estetrol (E4) can help hair grow longer by extending its growth phase.

The study concluded that fatty acid transport protein 4 in epidermal keratinocytes is crucial for maintaining normal skin structure, as its deficiency led to hyperkeratosis and epidermal barrier disruption in mice.

This study identified a new gene, mrp4, in mice, which suggests it may have a unique role in the growth and development of hair follicles in the ears and tails.

ATR04-484 ointment shows promise for treating skin issues from cancer therapies.

This study found that the natural estrogen Estetrol (E4) may promote hair follicle growth and prevent miniaturization, suggesting its potential as a treatment for hair loss disorders.

This study reports that PADI4, an enzyme involved in posttranslational protein modifications, regulates progenitor cell transitions in hair follicle development by repressing transcription and interacting with translational and ribosomal processes.

This study found that progesterone enhances the survival of newborn neurons in the hippocampus of adult male mice, which is associated with improved spatial learning and memory.

This study found that Ecklonia cava polyphenols increased human dermal papilla cell proliferation and extended hair shaft length in vitro and ex vivo, suggesting potential as a therapeutic candidate for hair loss.

In this clinical trial, the topical agent AP-FHG0604T significantly increased hair counts and growth rates in women with female pattern hair loss compared to a placebo, though some reported mild local irritation.

This study reveals that CSPG4-positive basal cell keratinocytes show distinct global gene expression from CSPG4-negative cells, despite similar colony-forming efficiency.

This study found that SSEA-4 is a marker that distinguishes eccrine from apocrine ductal cells in human sweat glands, suggesting its potential use in diagnostic applications.

This study found that platelet factor 4 in platelet-rich plasma suppresses human hair follicle growth and alters related gene expressions, suggesting potential implications for its use in hair loss treatment.

In this study, estetrol (E4) treatment was associated with increased hair growth in ex vivo human hair follicles, suggesting its potential as a treatment for hair loss disorders.

This study found that DPP4 is significantly involved in matrix deposition and fibrosis in human skin fibroblasts, although the exact functions of DPP4 remain unclear.

This study found that overexpression of sFRP4 in skin cells reduces Wnt signaling activation, leading to decreased melanocyte differentiation in regenerating hair follicles.

This study identifies two previously unreported pathogenic RIPK4 gene variants, suggesting a functional link with cell adhesion molecules in ectodermal dysplasias.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

This study observed that PCE-DP may improve skin pigmentation by increasing epidermal turnover and inhibiting melanin uptake and inflammation in human epidermal keratinocytes.

This study identified that Eda-A1 unexpectedly induces placode inhibitors dkk4 and lrp4, indicating the importance of tightly regulated signaling for proper ectodermal organ development.

This study suggests that EREG, released from ORS cells, may promote hair growth by activating specific receptors and modulating ROS generation, offering a potential new treatment for hair loss.

This study found that progesterone increased the survival of newborn neurons and enhanced spatial learning and memory in adult male mice, independent of neuron production changes.

This study found that histopathologic features of erythematous papulopustular eruption due to EGFR inhibitors vary with eruption severity and differ between cetuximab and erlotinib treatments.

This study found that polyamidoamine dendrimers can permeate skin's current conducting pores and alter the magnitude and direction of electroosmotic flow, affecting drug flux during iontophoresis.

This study found that in Liaoning cashmere goats, the BMP4 gene shows increased transcription from the anagen stage to telogen, and higher gene methylation correlates with reduced expression in skin tissue.

This study identified a new FAK isoform, FAKΔe4, which is regulated by ECM stiffness and affects cell migration, invasion, and mechanosensing in human-derived data and engineered models.

This study found that cPPARγ and dnPPARγ isoforms are differentially expressed in healthy human skin, suggesting that PPARγ modulators may have compartment-specific effects depending on isoform presence.

This study found that the peptide derivative beta-Ala-Pro-Dab-NHbenzyl may reduce wrinkles and sebum production in human skin by inhibiting dipeptidyl peptidase 4, suggesting potential for acne and skin inflammation treatment.