21 citations,
January 2020 in “General and Comparative Endocrinology” Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
21 citations,
April 2018 in “Journal of Dermatological Science” Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.
21 citations,
August 1994 in “Clinical endocrinology” 5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.
20 citations,
December 2013 in “Journal of Dermatology” UV-B light increases inflammation-related substances in acne-related skin cells.
20 citations,
June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery” Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.
20 citations,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” Minoxidil and finasteride can help with hair loss, but more research is needed to improve treatments for certain types of hair loss.
19 citations,
July 2015 in “Journal of inherited metabolic disease” Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.
19 citations,
April 2015 in “European Journal of Pharmacology” Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.
19 citations,
October 2012 in “Frontiers of Hormone Research” Lifestyle changes are the first step in treating infertility in PCOS, followed by medications like clomiphene and metformin, and then surgery if needed.
19 citations,
February 2010 in “Journal of Chemical & Engineering Data” Flutamide, dutasteride, and finasteride dissolve differently in supercritical carbon dioxide, with dutasteride dissolving the least.
19 citations,
July 2007 in “Dermatologic clinics” Tailor treatments for vitiligo to patient needs for best results.
18 citations,
May 2020 in “Biomolecules” Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.
18 citations,
March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
18 citations,
August 2015 in “Biochemical and Biophysical Research Communications” XEDAR triggers a specific signaling pathway in cells.
18 citations,
October 2014 in “Experimental Dermatology” Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.
17 citations,
April 2007 in “Kidney international” Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.
16 citations,
March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.
15 citations,
May 2020 in “BMC complementary medicine and therapies” Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.
15 citations,
July 2017 in “PubMed” Injecting a mix of human skin and hair cells into mice can grow new hair.
15 citations,
November 2015 in “Journal of Cosmetic Dermatology” Botanicals like green tea extract show potential for hair growth, but more research is needed.
15 citations,
February 2015 in “Han-gug chugsan sigpum hag-hoeji/Korean journal for food science of animal resources” Egg shell membrane hydrolysates can reduce wrinkles and improve skin health.
15 citations,
August 2006 in “Journal of Cutaneous Pathology” HIV-1 may cause increased stem cell death in hair follicles, leading to hair loss.
14 citations,
July 2019 in “Experimental and Molecular Medicine” Nanog gene boosts stem cells, helps hair growth, and may treat hair loss.
14 citations,
October 2018 in “Brain Research Bulletin” Exosomes help nerve fibers grow by affecting specific cell signaling pathways.
14 citations,
January 2013 in “Indian Journal of Endocrinology and Metabolism” Women with congenital adrenal hyperplasia have lower fertility, but with proper treatment, they can conceive successfully.
14 citations,
March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Patients with severe alopecia areata have higher levels of MIF, which decrease after successful treatment.
14 citations,
April 2000 in “Animal Science/Animal science” Nutrients like vitamins, copper, zinc, and amino acids are crucial for healthy hair and wool growth.
13 citations,
August 2020 in “Frontiers in Cell and Developmental Biology” Twist1 helps maintain important features of cells crucial for hair growth by working with Tcf4 and β-catenin.
13 citations,
June 2020 in “Stem Cells International” A substance from a specific gel helped to grow hair effectively in mice, suggesting it could potentially be used to treat hair loss in humans.
13 citations,
December 2014 in “Stem Cells” Hair and skin can regenerate without bulge stem cells due to other compensating cells.