research Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis
Two distinct caspases in human skin help with cell death and skin formation.
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480-510 / 1000+ resultsresearch Ornithine Decarboxylase as a Target for Chemoprevention of Basal and Squamous Cell Carcinomas in Ptch1+/– Mice
Targeting ornithine decarboxylase can help prevent skin cancer.
research PCSK9: From Nature's Loss to Patient's Gain
Certain genetic mutations can lower bad cholesterol and reduce heart disease risk, leading to effective cholesterol-lowering drugs.
research Vitamin D Resistance
Vitamin D and its receptor are essential for hair growth, cell regulation, immune function, and heart health.
research New Frontiers in CRISPR/Cas9 Delivery Systems for Gene Editing
Efficient delivery systems are needed for the clinical use of CRISPR-Cas9 gene editing.
research The Human Skin as a Hormone Target and an Endocrine Gland
Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.
research Intracrine Androgen Biosynthesis, Metabolism, and Action Revisited
The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
research In Vivo Function of VDR in Gene Expression: VDR Knock-Out Mice
Vitamin D receptor is crucial for bone health and mineral metabolism.
research Evidence for 1,25-Dihydroxyvitamin D3-Independent Transactivation by the Vitamin D Receptor
The vitamin D receptor can work without its usual activating molecule.
research The 1,25-Dihydroxyvitamin D3-Independent Actions of the Vitamin D Receptor in Skin
The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.
research Immuno-Endocrinology of COVID-19: The Key Role of Sex Hormones
Sex hormones may affect COVID-19 severity, with estrogen possibly reducing risk and testosterone potentially increasing it.
research May Patients Receiving 5-Alpha-Reductase Inhibitors Be at Higher Risk of COVID-19 Complications?
Men on 5-alpha-reductase inhibitors might have worse COVID-19 outcomes.
research Antimicrobial Peptide Lysozyme Has the Potential to Promote Mouse Hair Follicle Growth In Vitro
Lysozyme might help mouse hair grow.
research Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production
Tetrathiomolybdate reduces hair growth marker in skin cells by boosting harmful oxygen molecules, but effects can be reversed.
research Isotretinoin Treatment Upregulates the Expression of P53 in the Skin and Sebaceous Glands of Patients with Acne Vulgaris
Acne treatment with isotretinoin increases the presence of p53, a protein, in skin and oil glands, which may help reduce acne severity.
research Androgens and Androgen Receptor in the Management of Skin Diseases
Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.
research Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells
Escin may help treat hair loss by boosting a specific cell growth pathway.
research Diphenyl Cresyl Phosphate [MAK Value Documentations, 2003]
Diphenyl cresyl phosphate has low toxicity but can harm the liver, kidneys, adrenal glands, and testicles at high doses.
research Antiepileptogenic Effects of Trilostane in the Kainic Acid Model of Temporal Lobe Epilepsy
Trilostane may help delay epilepsy development by increasing certain brain chemicals.
research Reversible Activation of c-Myc in Skin
Activating c-Myc in skin causes rapid cell growth and changes, but these effects are reversible.
research Vitamin D: More Than a Bona Fide Hormone
Vitamin D is important for bones, hair, blood pressure, and breast development.
research Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion
Notch signalling helps skin cells differentiate and prevents tumors.
research Genetic Disorders and Defects in Vitamin D Action
Two rare genetic diseases cause severe rickets in children due to defects in vitamin D metabolism.
research Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets
Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.
research The Skin as an Endocrine Organ
The skin produces and processes hormones, affecting both local and overall body functions.
research PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology
PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.
research Simultaneous Quantitation of Nine Hydroxy-Androgens and Their Conjugates in Human Serum by Stable Isotope Dilution Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry
A new method accurately measures nine specific hormones in human blood.
research Role of OCT4 in the Regulation of FSH-Induced Granulosa Cell Growth in Female Mice
OCT4 helps granulosa cell growth in early-stage follicles, and FSH increases OCT4 through specific pathways.
research Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers
The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.
research Male and Female Pattern Hair Loss: Treatable and Worth Treating
Treating hair loss in both men and women is effective and improves quality of life.