research Chapter 14: Principles of Drug Metabolism
Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.
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research Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives
Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
research Molecular Interactions of New Pregnenedione Derivatives
The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
research Roles of Steroid Sulfatase in Brain and Other Tissues
Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.
research Teriflunomide (Aubagio) for the Treatment of Multiple Sclerosis
Teriflunomide is an effective and generally safe oral treatment for relapsing MS, reducing relapses and slowing disability progression.
research Promotion of Homology-Directed DNA Repair by Polyamines
Polyamines help fix DNA damage accurately in cells.
research Markers of Peripheral Androgen Action In Vivo and In Vitro
Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.
research Epimedium Brevicornum Maxim Extract Enhances Melanin Biosynthesis and Melanosome Biogenesis/Transfer
Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.
research Steroid Sulfatase Inhibitors: Role and Therapeutic Potential
Steroid sulfatase inhibitors could potentially treat hormone-related disorders like certain cancers, hair loss, acne, and improve cognitive dysfunction.
research Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice
Glycerol is essential for skin hydration in mice without sebaceous glands.
research Enzymes
Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
research Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria
Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.
research Enzyme-Linked Immunosorbent Assays for Doping Control of 5α-Reductase Inhibitors Finasteride and Dutasteride
New tests detect finasteride and dutasteride in urine quickly and easily.
research Health Promotion Potential of Vegetables Cultivated in Northern Thailand: A Preliminary Screening of Tannin and Flavonoid Contents, 5α-Reductase Inhibition, Astringent Activity, and Antioxidant Activities
Some vegetables from Northern Thailand show promise for health benefits, including hair loss treatment and antioxidant properties.
research Characteristics And Alopecia Activity Of Pakis Gajah (Angiopteris Evecta) Growing In Galunggung Mountainside, West Java
Pakis Gajah (Angiopteris evecta) water extract may promote hair growth in rabbits, but more research is needed for human use.
research Hair Growth Promoting Activity of Langir Bark (Albizia Saponaria Lour.) Ethanol Extract: In Vivo Assay
Albizia saponaria bark ethanol extract, particularly at 15%, promotes hair growth in rabbits.
research Activity of Angiopteris Evecta for Baldness Treatment
Angiopteris evecta extracts significantly promote hair growth in rabbits.
research Sphingolipid Metabolism Orchestrates the Establishment of the Adult Hair Follicle Stem Cell Niche to Control Skin Homeostasis
A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.
research Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ
DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.
research Novel Inhibitors of 5α-Reductase
New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.
research Sexual Hormones in Human Skin
Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.
research Recent Advances in Oxasteroids Chemistry
New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.
research The Human Gut Chemical Landscape Predicts Microbe-Mediated Biotransformation of Foods and Drugs
The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.
research Foliar and Root Applications of Vegetal-Derived Protein Hydrolysates Differentially Enhance the Yield and Qualitative Attributes of Two Lettuce Cultivars Grown in Floating System
Protein hydrolysates applied to roots or leaves differently improved lettuce yield and quality, with the best results seen in specific combined treatments for each type.
research Effects of Egg Shell Membrane Hydrolysates on UVB-Radiation-Induced Wrinkle Formation in SKH-1 Hairless Mice
Egg shell membrane hydrolysates can reduce wrinkles and improve skin health.
research Injectable Silver Nanoclusters-Based Hydrogel for Wound Healing by Eliminating Bacterial Infection and Promoting Tissue Regeneration
The hydrogel with silver and mangiferin helps heal wounds by killing bacteria and aiding skin and tissue repair.
research Synthesis and Biological Evaluation of Novel Unsaturated Carboxysteroids as Human 5α-Reductase Inhibitors: A Legitimate Approach
New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.
research Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist
CB-03-01 is a promising skin cream for treating hormone-related skin problems without causing harmful body-wide effects.
research Synthesis of Novel Iron Nanoparticles Using the Aqueous Extract of the Pumpkin Plant and Their Use in the Treatment of Burns
Iron nanoparticles made from pumpkin extract effectively treated burns and promoted healing in mice.
research Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair
Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.