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    Glossary Endothelin-1

    potent vasoconstrictor peptide regulating blood vessel constriction

    Endothelin-1 (ET-1) is a potent vasoconstrictor peptide produced by endothelial cells, which line the blood vessels. It plays a crucial role in regulating blood pressure and vascular tone. Elevated levels of ET-1 are associated with various cardiovascular diseases, including hypertension and heart failure.

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    Research 30 of 1000+

    1. Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts Laboratory Investigation · 2006 · 27 citations
    2. Endothelin-1 combined with extracellular matrix proteins promotes the adhesion and chemotaxis of amelanotic melanocytes from human hair follicles in vitro Cell Biology International · 2006 · 11 citations
    3. Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions Frontiers in Immunology · 2022 · 34 citations
    4. miR-150 regulates endothelial progenitor cell differentiation via Akt and promotes thrombus resolution Stem Cell Research & Therapy · 2020 · 20 citations
    5. Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression Nature cell biology · 2023 · 5 citations
    6. Transgneic Endothelin 3 Regulates Murine Pigment Production and Coat Color 2017
    7. 15-Hydroxyprostaglandin Dehydrogenase Inhibitor Restores Endothelial Function Under Dihydrotestosterone-Induced Stress in Human Dermal Microvascular Endothelial Cells Molecules · 2025
    8. 17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells 2002 · 18 citations
    9. Topical tacrolimus suppresses the expression of vascular endothelial growth factor and insulin-like growth factor-1 in late anagen Clinical and Experimental Dermatology · 2009 · 6 citations
    10. 127 NDRG1 regulates proliferation of endothelial cells of infantile hemangioma Journal of Investigative Dermatology · 2018
    11. Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute Stem cell research & therapy · 2014 · 45 citations
    12. [Experimental study on vascular endothelial growth factor 165 gene-modified rat hair follicle stem cells mediated by lentiviral vector]. PubMed · 2014
    13. Vascularization of skin substitute constructed by vascular endothelial growth factor 165 gene-modified hair follicle stem cells compounded with three-dimensional gelatin-chondroitin sulfate-hyaluronic acid 2014
    14. Loss‐of‐function of Endothelin receptor type A results in Oro‐Oto‐Cardiac syndrome American Journal of Medical Genetics Part A · 2020 · 11 citations
    15. A window into the vascular endothelium in COVID-19: Nails Dermatology Practical & Conceptual · 2025 · 2 citations
    16. 17β-Estradiol Increases APE1/Ref-1 Secretion in Vascular Endothelial Cells and Ovariectomized Mice: Involvement of Calcium-Dependent Exosome Pathway Biomedicines · 2021 · 9 citations
    17. Author response: Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta 2019
    18. Decision letter: Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta 2019
    19. [Expressions of bFGF, ET-1 and SCF in dermal papilla cells and the relation to their biological properties]. PubMed · 2004 · 1 citations
    20. Fibroblasts and endothelial cells interplay drives hypertrophic scar formation: Insights from in vitro and in vivo models Bioengineering & Translational Medicine · 2023 · 21 citations
    21. Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis Pharmacological Research · 2024 · 5 citations
    22. Metabolic and Vascular Inflammation in Alopecia Areata: Linking Uric Acid, Lipid Imbalance and ICAM ‐1 Upregulation Experimental Dermatology · 2025
    23. Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular cells bioRxiv (Cold Spring Harbor Laboratory) · 2023
    24. SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism Viruses · 2021 · 50 citations
    25. Targeted Overexpression of the Angiogenesis Inhibitor Thrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis and Cutaneous Photo-Damage Journal of Investigative Dermatology · 2002 · 93 citations
    26. C‐reactive protein promotes adhesion of monocytes to endothelial cells via NADPH oxidase‐mediated oxidative stress Journal of Cellular Biochemistry · 2012 · 24 citations
    27. Topical treatment with the bacterium-derived c-Met agonist InlB321/15 accelerates healing in the abrasion wound mouse model Archives of Dermatological Research · 2018 · 3 citations
    28. 354 Investigating early molecular changes in a model of x-ray radiation-induced alopecia: spotlight on growth arrest and endothelial dysfunction Journal of Investigative Dermatology · 2025
    29. 708 SIG-1451: A topical anti-inflammatory new chemical entity for atopic dermatitis (AD) Journal of Investigative Dermatology · 2017
    30. Different Levels of EGF, VEGF, IL-6, MCP-1, MCP-3, IP-10, Eotaxin and MIP-1𝛼 in Adipose Derived Stem Cells (ADSCs) Secretome in Androgenetic Alopecia 2021