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Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.

This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.

This study suggests that while platelet-rich products show promise in treating dermatological conditions like chronic wounds and skin aging, there is still a need for standardized methodologies and extensive trials to confirm their long-term clinical benefits.

This review outlines recent advancements in biomimetic materials for skin regeneration, emphasizing their potential to mimic tissue structures and regulate physiological processes, and discusses future directions involving novel technologies like artificial intelligence and in situ reprogramming.

This study demonstrated that combining AMD3100 with low-dose tacrolimus in a stem cell mobilization approach significantly reduced wound healing time and improved scar and hair follicle regeneration in full-thickness skin wounds.

In this study involving adult mice, the researchers identified that double-stranded RNA-mediated activation of toll-like receptor 3 stimulates wound-induced hair neogenesis, potentially reflecting mechanisms used in facial rejuvenation treatments.

This study demonstrated that pharmacologically mobilizing endogenous bone marrow stem cells with AMD3100 and low-dose FK506 can enhance liver regeneration and improve liver function in rats after extensive hepatectomy.

This study developed a novel zinc-releasing hydrogel, Zn-Gel, which promoted wound healing by controlling zinc ion release and demonstrated excellent compatibility and efficacy in enhancing cell proliferation, blood vessel formation, and tissue regeneration in vitro and in vivo settings.

This review examines current treatments and the potential role of stem cells in cutaneous wound healing, but it presents no new clinical results and calls for more research on mechanisms.

This study demonstrated that an engineered human skin equivalent can generate follicle-like structures resembling fetal skin, highlighting the role of the dermal compartment in directing epithelial cell fate in vitro.

This review examines the recent progress in using bioactive molecules for skin regenerative medicine and reports no new clinical results; the authors suggest this method could become a promising strategy for in situ skin regeneration.

This review highlights emerging evidence that biophysical and metabolic cues, such as oxygen levels and tissue mechanics, significantly influence skin stem cell behavior, which is crucial for developing advanced wound healing therapies beyond traditional infection and inflammation control.

This article provides contact information for Bruce A. Morgan and features no new research findings.

This review highlights the potential of nanotechnology for hair follicle regeneration, focusing on strategies such as hair cycle modulation, progenitor cell stimulation, and wound-induced hair neogenesis, while also discussing regulatory challenges that may affect the development of these innovative approaches.

This review discusses the development and future prospects of biomaterials for in situ tissue regeneration but reports no new research results; it underscores the importance of biomaterials in addressing tissue defects.

This study found that the 3' UTR of JAM-A acts as a key competing endogenous RNA that supports dermal papilla cell function and hair follicle regeneration in alopecia areata.

This review explores the role of hair follicle dermal stem cells in skin regeneration and restorative therapies, but it reports no new experimental results.

This review discusses the potential of endogenic and exogenous exosomes in dermatology and cutaneous aesthetics, highlighting their capacity to repair and rejuvenate skin tissue, but reports no new experimental results.

This review discusses the role of jasmonic acid and its conjugates in enhancing plant stress tolerance and balancing growth and defense mechanisms but provides no new experimental data.

This article explores the therapeutic potential of TECAR therapy for physiotherapy, highlighting its non-invasive nature and ability to provide analgesic, anti-inflammatory, and tissue healing effects across various conditions with minimal side effects when applied correctly.

This study developed a tannin-modified cellulose-polypyrrole dressing that accelerates wound healing by enhancing granulation tissue, optimizing collagen, and stimulating angiogenesis, while providing antibacterial protection against S. aureus and E. coli.

This review describes bioengineering strategies to mimic the natural cell microenvironment in vitro, emphasizing the novel approach of using cell-synthesized extracellular matrix as a scaffold for engineering functional 3D tissues, while highlighting the limitations of exogenous scaffolds in tissue engineering.

This review summarizes recent findings on how Wnt signaling proteins play crucial roles in the cutaneous wound healing process but reports no new clinical results.

A specific RNA increases hair stem cell growth and skin healing by affecting a protein through interaction with a microRNA.

This review discusses the role of lncRNA Xist in cell growth regulation and disease development, particularly cancer, and reports no new experimental results.

This study describes a protocol for inducing endogenous reactive oxygen species in mouse skin, which stimulates tissue regeneration and promotes burn healing and hair follicle growth.

This mini-review explores how both endogenous and damage-released RNAs serve as instructional signals that influence cell identity and plasticity during tissue maintenance and repair, highlighting RNA's role as a regulator of cellular flexibility in various regenerative contexts.

This study found that recombinant keratinocyte growth factor (rKGF) stimulated hair growth and provided a protective effect against alopecia in murine models, suggesting its role in hair follicle development and regeneration.