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Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Men and women react differently to opioids, with hormones potentially influencing these differences.

The study concluded that the most common skin problems in women with PCOS are excess hair, acne, oily skin, hair loss, dark skin patches, and skin tags.

High levels of prolactin in the blood can be linked to widespread hair loss.

Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.

Female pattern hair loss can be treated with medications, surgery, and cosmetic products, considering its psychological impact.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Female pattern hair loss involves thinning hair on crown and frontal scalp, diagnosed by hair ratio, and treated with minoxidil, antiandrogens, or hair transplantation.

Hair growth dysfunction involves various conditions with limited treatment options.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

PCOS is a hormonal disorder causing infertility and menstrual problems, often linked to obesity and can lead to acne, treated with hormonal and insulin-sensitizing medications.

Hair loss in women is often due to hereditary conditions or stress, and while treatments like minoxidil can help, diagnosis and management require medical guidance.

Acne not improved by usual treatments may indicate a genetic disorder.

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

The FG score is better at detecting hyperandrogenism in PCOS patients than testosterone levels or FAI, but testosterone is the recommended test for diagnosis.

Testosterone replacement therapy should be used for men with low testosterone levels and symptoms of hypogonadism, after careful diagnosis and considering individual needs.

Women with hair loss should be checked for PCOS, as it's often related and early diagnosis can help with treatment.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Many alopecia patients have undetected thyroid abnormalities that can be found through physical exams.

The conclusion is that early diagnosis and a multi-system treatment approach are crucial for managing PCOS and its associated health risks.

APS-1 in Italy shows diverse AIRE mutations and various autoimmune issues.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Updated treatments for female hair loss include minoxidil, antiandrogens, hair transplants, and light therapy.

The document concludes that early and personalized treatment for PCOS in adolescents is crucial to manage symptoms and prevent long-term health issues.

Minoxidil and finasteride are effective for male hair loss, minoxidil for female hair loss, and various treatments like corticosteroids work for alopecia areata; treatment should be tailored to the individual.

An mFG score of 7 or higher indicates hirsutism in Filipino women, often linked to higher free testosterone levels.

The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.

Bariatric surgery patients need careful before and after surgery care for safety and long-term health.