37 citations
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June 2017 in “Journal of Investigative Dermatology” This study suggests that the interaction between CXXC5 and Dishevelled is a potential target for promoting hair regrowth and hair follicle formation, offering a new approach to treat hair loss.
22 citations
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November 2016 in “International journal of molecular sciences” This study suggests that impaired VDR signaling in mice leads to dysregulated Ddit4 expression, impacting hair cycle progression and wound healing.
9 citations
,
July 2022 in “Cell reports” This study found that Sox2 within dermal papilla cells in the hair follicle regulates hair pigmentation, influencing the type and production of melanin.
October 2025 in “Biomolecules” This study found that prolonged intermittent fasting in diet-induced obese mice led to increased levels of inositol monophosphates in white adipose tissue, improved insulin sensitivity, and reduced body weight and fat mass, suggesting a novel metabolic adaptation mechanism.
10 citations
,
March 2024 in “Endocrine Reviews” In this retrospective review, the author discusses key discoveries in understanding androgen excess disorders like PCOS, focusing on genetic and molecular insights gained from 1965 to 2015.
2 citations
,
September 2016 in “Journal of skin and stem cell” This study observed that acne was strongly associated with higher BMI, alopecia, menstrual dysfunction, positive familial history, and overuse of sweet and fatty foods among dermatology patients.
59 citations
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July 2023 in “PLoS ONE” This study reveals a high prevalence of multiple sclerosis in Africa, indicating an epidemiological shift in the region and underscoring the need for early prevention and treatment strategies.
March 2023 in “Translational Andrology and Urology” This review discusses the pharmacology of 5-alpha reductase inhibitors, their expanding clinical indications beyond benign prostatic hyperplasia, and notes unresolved claims about their potential role in SARS-CoV-2.
81 citations
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February 2014 in “EMBO molecular medicine” This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH.
45 citations
,
May 2024 in “International Journal of Molecular Sciences” This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.
22 citations
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January 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study developed and validated a mass spectrometric method to measure hydroxy-androgens in serum, which aids in understanding androgen synthesis in castration resistant prostate cancer.
20 citations
,
August 2020 in “Scientific Reports” In this study, low-dose BPA was associated with induced prostatic hyperplasia in rats, potentially mediated by COX-2 and L-PGDS through pathways involving cell proliferation and apoptosis.
14 citations
,
May 2012 in “Endocrine Research” This study found diverse responses to the androgen dihydrotestosterone in rodent tissues, with most androgen-regulated processes being specific to particular tissues.
7 citations
,
July 2019 in “International archives of internal medicine” This review discusses the psychological and emotional effects of common dermatologic conditions and highlights their impact on quality of life, but it does not present new clinical results.
3 citations
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September 2021 in “International Journal of Molecular Sciences” This study suggests that women with polycystic ovary syndrome may have an increased risk of COVID-19-related cardiac and renal complications, and that weight loss through lifestyle changes could help reduce these risks.
2 citations
,
January 2022 in “Oxidative Medicine and Cellular Longevity” This study suggests that exosomes from dermal papilla cells can regulate hair follicle stem cell proliferation via the Wnt3a/β-catenin signaling pathway, potentially informing treatment for human hair problems.
August 2022 in “IntechOpen eBooks” This article reviews congenital adrenal hyperplasia, a group of rare genetic disorders affecting steroid synthesis, and highlights the need for specific therapy and ongoing monitoring, but reports no new clinical findings.
March 2022 in “Women's health issues” This review highlights the urgent need for increased research and policy support for autoimmune and immune-mediated skin diseases, which are on the rise and disproportionately affect women's health in the United States, suggesting a focus on gender and socioenvironmental factors.
January 2025 in “BMC Pediatrics” In this study conducted among healthy Iranian girls in Isfahan province, researchers found that the median onset age for menstruation was 12.05 years, breast development began at 9.89 years, and pubic hair development started at 10.14 years, with earlier puberty onset potentially indicating precocious puberty.
March 2024 in “Translational Journal of the American College of Sports Medicine” This study highlights that feeding and eating disorders, as well as disordered eating behaviors, are more prevalent among athletes compared to the general population, emphasizing the critical role of athletic trainers in early identification and management.
January 2024 in “Journal of lipid research” In this study, finasteride was found to reduce cholesterol levels and delay atherosclerosis in LDL receptor-deficient mice, and men using finasteride reported lower cholesterol levels, suggesting potential cardiovascular benefits by improving lipid profiles.
This study found that UV radiation-induced fibroblast depletion in the skin is primarily due to a deregulated inflammatory response, with T cells aiding fibroblast survival under stress.
April 2020 in “BMC endocrine disorders” This case report describes a 65-year-old woman with childhood-onset growth hormone deficiency who developed panhypopituitarism, including late-onset secondary hypoadrenocorticism, affecting her respiratory and renal function.
January 2023 in “WikiJournal of Medicine” This review discusses alternative androgen pathways, including the "backdoor" pathway and pathways to 11-oxygenated steroids, and reports no new clinical results; the authors aim to clarify these concepts for better patient treatment.
July 2025 in “Journal of Clinical Research and Reports” This abstract provides a narrative overview of polycystic ovary syndrome, discussing its symptoms and related health issues, and does not include new research findings.
2 citations
,
September 2025 in “Frontiers in Endocrinology” This review critically evaluates the evidence for SARMs' tissue selectivity and suggests their clinical benefits over traditional androgens are not yet well-supported by robust evidence, underscoring the need for further head-to-head trials.
9 citations
,
September 2024 in “Frontiers in Endocrinology” This study found that intrauterine PRP infusion is a safe and effective treatment for patients with refractory thin endometrium and implantation failures, with the improvement primarily driven by the angiogenic cytokines in PRP.
3 citations
,
June 2024 in “Frontiers in Endocrinology” In this study, COC treatment led to greater improvements in sex hormone, endocrine factor, and metabolic levels among PCOS patients compared to those who did not receive the treatment.
October 2025 in “Frontiers in Endocrinology” This study confirmed that methimazole use is associated with agranulocytosis, pyrexia, exposure during pregnancy, and hyperthyroidism, while also identifying new safety signals like premature birth and septic shock that require further investigation.
August 2025 in “Frontiers in Endocrinology” This study examined postmenopausal hyperandrogenism related to ovarian disease and found that specific biochemical markers can help differentiate between tumorous and non-tumorous cases, with a good level of sensitivity and specificity, supporting surgical intervention for resolution.