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Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

A certain gene variation is linked to a higher risk of polycystic ovarian syndrome in South Indian women.

Eating healthy and exercising can help manage Polycystic Ovarian Syndrome and its related health problems.

Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.

Higher BPA levels may be linked to idiopathic hyperandrogenemia in women.

Resistance training might help with PCOS symptoms, but more research is needed.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Testosterone therapy is beneficial for women's health and does not cause masculinization or liver damage, and it protects the heart and breasts.

Hormonal therapies are safe and effective for treating adult women's acne.

Prostate-specific antigen may be a new marker for excess male hormones in women with polycystic ovary syndrome.

Tissue-derived extracellular vesicles are crucial for cancer diagnosis, prognosis, and treatment.

The document concludes that careful history and physical exams are crucial for accurately diagnosing polycystic ovary syndrome and distinguishing it from other similar conditions.

Vitamin D receptor may help protect against UV-induced skin cancer.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Women with PCOS should have an oral glucose tolerance test for effective diabetes screening.

Some plants used in traditional medicine may help treat cancer because they contain proteins that can inactivate ribosomes.

Transdermal testosterone can improve sexual desire in postmenopausal women but lacks long-term safety data and is not FDA-approved for this use.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Most women with hirsutism have it because of PCOS, and they need long-term treatment including medication and hair removal to improve their condition.

Shift work disrupts the body's natural clock, leading to health problems.

Rutin may help treat symptoms of polycystic ovary syndrome (PCOS) in rats.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Medications for PCOS don't seem to raise heart disease risk.

The VEGF +405G allele may increase the risk of PCOS in South Indian women.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.