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A boy with a new NR5A1 gene mutation has a sex development disorder without affecting his adrenal glands.

A transman experienced lasting virilization symptoms after stopping testosterone, which were resolved with estradiol treatment.

A woman's small ovarian tumor causing high androgen levels was missed by several scans but found during surgery.

Excessive iodine from a cystic fibrosis supplement can cause hypothyroidism.

Diagnosing osteoporosis in transgender people is challenging due to unclear guidelines and hormone treatment effects.

Immunotherapy for cancer caused a patient to develop a condition affecting hormone production, requiring ongoing hormone replacement therapy.

Taking biotin can lead to incorrect low results in free testosterone tests.

A rare ovarian tumor caused high testosterone and excess hair in a woman, which was resolved after tumor removal.

A woman with ectopic Cushing's syndrome and COVID-19 passed away despite treatment.

Long-term treatment with buprenorphine/naloxone for opioid addiction may lead to secondary adrenal insufficiency.

A 21-year-old male with a rare genetic disorder experienced sudden hair loss and high DHEAS levels, likely due to a condition similar to PCOS, usually seen in women.

Estrogen deficiency can reduce the enzyme activity needed to activate vitamin D.

A woman's masculine features were caused by a rare ovarian tumor that produced male hormones.

The patient likely has Chrousos syndrome, a rare condition causing insensitivity to glucocorticoids, requiring high-dose dexamethasone treatment.

A woman's masculine symptoms were caused by a rare tumor in her left ovary, which was found using a special blood test.

Always consider xanthomatous hypophysitis before deciding on pituitary surgery.

Removing the ovarian tumor improved the woman's hormonal symptoms.

An 8-year-old boy's early puberty was caused by a rare hormone-secreting brain tumor, which was successfully treated with surgery.

A man's rare adrenal tumor caused feminization and white hair, was removed surgically, and improved after treatment.

A woman developed male characteristics after using unregulated hormone therapy.

Adolescents with PCOS have higher levels of certain androgens, which are linked to hair growth but don't help diagnose PCOS better than testosterone levels.

A patient produced cortisol after adrenalectomy, possibly due to residual tissue or other body parts making steroids.

Transgender females can reach their target estrogen levels using estradiol patches, especially if oral treatments fail or if they're at risk for blood clots. Often, the highest dose patch is needed.

A woman's severe hormone imbalance after menopause led to finding a rare ovarian tumor, treated by surgery.

A rare ovarian cancer with a good outlook was found in a woman with unusual hair growth and abdominal symptoms.

A 23-year-old woman's missed periods were caused by a rare genetic disorder treated with hormone patches.

A woman's hair loss and other symptoms were due to a rare hormone deficiency treatable with steroids.

Long-term opioid use can cause a serious condition where the adrenal glands don't work properly, which doctors should watch out for.

A woman with a rare ovarian tumor and hyperparathyroidism improved after surgery, highlighting the need for reporting unusual cases to understand and manage rare diseases.

Taking thyroid medication reduced the patient's pituitary gland swelling and improved her symptoms.