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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

Aging scalp skin contributes to hair aging and loss, and more research is needed to develop better hair loss treatments.

Losing 5-10% body weight can improve PCOS symptoms, letrozole is better than clomiphene for fertility, and managing weight and blood sugar is important to reduce pregnancy complications.

Topical minoxidil improves hair loss in 80% of women with breast cancer undergoing endocrine therapy.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

Flutamide, an antiandrogen, has minimal impact on female rat endocrine systems and does not significantly change their reproductive cycles.

Hormonal therapies are safe and effective for treating acne in female adolescents, with specific treatments for those with endocrine disorders.

Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Kids with alopecia areata may experience more stress but not necessarily feel more anxious or depressed than others.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

Hormone imbalances can cause skin diseases, and understanding these links is important for diagnosis and treatment.

Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.

Environmental cues can change the fate and function of epithelial cells, with potential for cell therapy.

Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.

PCOS is caused by both genetics and environmental factors like diet and obesity.

Different types of polycystic ovary syndrome (PCOS) have varying severity, with Type I being the most severe and common.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

Male-pattern baldness might be caused by the effect of hormones on scalp blood vessels.

Diet changes can protect against harmful environmental effects on fetal development.

Adult skin quickly reacts to short-term environmental and internal stress, leading to various skin issues and the need for protective measures.

Melatonin protects skin against UV damage by regulating various cellular processes.

South Asian women with PCOS are more likely to have metabolic issues and central obesity, and simple measures like waist size and blood pressure can help identify these risks early.

The paper concludes that drug labels should be clear for all, especially for those with low literacy, and suggests aiming for high comprehension test passing rates with diverse test populations.