27 citations
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September 2017 in “Journal of Medicinal Food” In this study, researchers found that a polyphenolic extract from Annurca apples, high in procyanidin B2, increased hair growth, density, and keratin content in healthy subjects after 2 months of use, and stimulated keratin biosynthesis in vitro.
26 citations
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January 2013 in “BioMed Research International” This review discusses the hormonal influences on hair cycling disorders in post-partum and postmenopausal women and notes the lack of evidence for effective targeted treatments.
26 citations
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November 1993 in “Progress in Neuro-psychopharmacology & Biological Psychiatry” This study reported that prenatal exposure to dihydrotestosterone altered long-term androgen metabolism in juvenile male rats, suggesting different regulatory mechanisms for 5a-reductase in hypothalamic versus pituitary tissues.
23 citations
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April 2010 in “Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology” This study found that exposure to sex steroid biosynthesis inhibitors increases the expression of piRNA pathway genes in frog larvae, suggesting these genes play a role in gonadal sex differentiation.
21 citations
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December 2019 in “PloS one” In this study, the authors concluded that the VCD-induced follicular depletion rat model can effectively simulate the perimenopause transition, with hormonal changes distinguishing early/mid-transition from late transition to estropause.
20 citations
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October 2021 in “PLoS ONE” This study found significant differences in gene expression between newborn and adult skin, with infant skin notably increasing processes related to ECM organization, cell adhesion, and collagen fibril organization.
18 citations
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January 2019 in “Animal Biotechnology” This study found that lncRNA-000133 may play a role in secondary hair follicle reconstruction and cashmere fiber growth in goats, potentially through its interaction with the methylation of its regulatory region and dermal papilla cells.
18 citations
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October 2014 in “Experimental Dermatology” Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.
18 citations
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June 1988 in “Culture, medicine and psychiatry” This paper examines how societal constructs of gender influence the treatment of idiopathic hirsutism in women, emphasizing the impact of perceived femininity on psychological stress and commercial depilatory actions.
16 citations
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April 1978 in “Genetics Research” This study found that asebic mice exhibit abnormal sebaceous gland differentiation and insufficient sebum production due to defective regulation of cell processes, despite possessing normally developing sebaceous glands initially.
15 citations
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September 1984 in “Veterinary Clinics of North America: Small Animal Practice” The document explains various skin conditions in cats and how to diagnose and treat them.
14 citations
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September 2019 in “Eye” This review discusses the evidence for using oral medications to treat central serous chorioretinopathy, highlighting eplerenone as having the most support despite a lack of robust efficacy across studies.
12 citations
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May 1989 in “Postgraduate Medicine” This article discusses treatments for male pattern baldness, noting that minoxidil is effective for improving baldness at the scalp vertex in young men, and reports no new clinical results.
10 citations
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April 2016 in “Research and reports in transdermal drug delivery” This review discusses the potential of follicular drug delivery systems to target the pilosebaceous unit and reports no new research findings.
10 citations
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October 2012 in “Andrology” In this case study, researchers observed that steroidogenesis from adrenal androgens in prostate cancer tissues may explain progression in a 74-year-old man with low circulating testosterone.
10 citations
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August 2012 in “Current Problems in Pediatric and Adolescent Health Care” This review explores hair signs related to nutrition disorders, such as thin and dyspigmented hair, without presenting new clinical findings; the authors highlight unknowns regarding underlying causes.
9 citations
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December 2024 in “Clinical and Experimental Obstetrics & Gynecology” This review examines the impact of polycystic ovary syndrome on reproductive health, its pathophysiology, clinical manifestations, and emerging therapies, and reports no new findings; the authors emphasize the need for individualized treatment strategies.
9 citations
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January 1997 in “Endocrine Journal” This study found a significant association between patients' sex of rearing and external genitalia in those with gonadal dysgenesis, while noting lower testosterone levels compared to controls.
8 citations
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January 2022 in “Burns and trauma” This review discusses the role of extracellular vesicles from specific skin cells in wound healing, emphasizing their potential in regenerative medicine and reporting no new experimental results.
8 citations
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April 2020 in “Facial Plastic Surgery Clinics of North America” This abstract explains that androgenetic alopecia, a common hair loss disorder influenced by genetics and hormones like dihydrotestosterone, has FDA-approved treatments including minoxidil, finasteride, and photolaser therapy, but its genetic basis and susceptibility to environmental factors remain complex.
7 citations
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August 2025 in “European Journal of Endocrinology” The authors concluded that incorporating routine endocrinology consultations into transplant care could address CNI-related endocrine toxicities, but prospective studies are needed to assess the impact on graft and patient survival.
7 citations
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September 2024 in “International Journal of Molecular Sciences” This study found that 11-oxygenated androgens were higher in women with PCOS compared to those with idiopathic hirsutism, with no difference from controls, and higher Bisphenol A levels in obese women with PCOS may worsen metabolic issues.
7 citations
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September 2023 in “Cancer Treatment Reviews” This review highlights the possible impact of side effects from endocrine therapy on quality of life, emphasizing that these can lead to poor adherence and early treatment discontinuation in patients with hormone receptor positive early breast cancer, potentially worsening survival outcomes.
7 citations
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March 2017 in “Medical Hypotheses” This study suggests that dysfunctions and altered expression of aquaporins may play a role in PCOS-related disorders, potentially impacting folliculogenesis and integrating with the insulin-dependent hypothesis of PCOS pathogenesis.
7 citations
,
January 2017 in “Journal of cosmetology & trichology” This article discusses how nutritional and environmental factors, along with antioxidant supplementation, may improve hair growth by mitigating the effects of androgens and reports no new clinical results.
7 citations
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October 2003 in “Nonlinearity in Biology Toxicology Medicine” This review discusses attempts to confirm low-dose effects in rodent endocrine studies and reports no findings; variability in control groups hinders demonstrating weak effects.
7 citations
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July 1999 in “In Practice” This article discusses the diagnostic approach to symmetrical alopecia in dogs, particularly focusing on conditions affecting the endocrine glands and hair follicles, without presenting new research results.
6 citations
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October 2020 in “Endocrine journal” This case report identifies two specific mutations in the WRN gene in a 40-year-old female with Werner syndrome, highlighting the need for awareness of its early manifestations and treatment options.
6 citations
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April 2019 in “Endocrinology and Metabolism Clinics of North America” This study observed that testosterone therapy in transgender men enhances both physical and mental health, is safe in the short and middle term with proper follow-up, and highlights the need for endocrinologists to provide gender-affirming care despite its limited presence in medical education.
6 citations
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February 2017 in “Case Reports in Dermatology” This case report highlights that hair loss, though common in the general population, may be a rare presenting symptom of Cushing's disease, as observed in a woman with multiple dermatological signs of the condition.