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This review covers the diverse applications of Cannabis sativa in areas like cancer treatment, skin care, and alopecia, but reports no new clinical results; continued research faces challenges due to legal variability.

This study found a 93.5% increase in nonvellus hair after 6 months of daily topical CBD application on the scalp in individuals with androgenetic alopecia, with no reported adverse effects.

This study identified that rose, thyme geraniol, palmarosa, and tolu balsam essential oils activate TRPV1, with citronellol and geraniol as newly recognized agonists.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

This study observed that N-palmitoylethanolamine (PEA) may relieve pain by enhancing de novo neurosteroid synthesis, evidenced by increased allopregnanolone levels and protein expression in pain models, dependent on PPAR-α.

This review explores the role of transient receptor potential vanilloid channels in the pathogenesis of osteoarthritis but reports no new clinical results.

This review discusses the potential use of cannabidiol (CBD) for managing COVID-19 patients, especially for controlling cytokine storms in those with acute respiratory distress syndrome, but reports no new clinical results.

This editorial discusses the rationale and limited evidence for "medical marijuana," suggesting that THC, an FDA-approved alternative, may often be a more appropriate choice for clinical use.

The researchers reported that epitestosterone treatment reduced eicosanoid levels generated by cyclooxygenases and lipoxygenases in rabbit liver samples with carrageenan-induced inflammation.

This study found that concentrations of THCCOOH in hair do not correlate well with self-reported cannabis use due to inaccuracies in the self-reported data, but it provides preliminary insights into usage patterns.

This study observed that a CBD-rich topical cannabis extract may increase hair count in patients with androgenetic alopecia when applied daily, but the effect is concentration-dependent and requires further research to establish safety and efficacy.

This study found that ointments containing indomethacin and its calcium salt showed potent anti-inflammatory effects on rat paw edema and arthritis with minimal skin irritation, suggesting potential for clinical use.

This study reported that novel kainate derivatives, especially ZCZ90, maintained potency in affecting proprioceptive sensory organ firing, aiding future receptor studies for potential treatment innovations.

In this study, researchers isolated new compounds from the plant *Calanthe cardioglossa* and found that five of these compounds, particularly calancardin B, significantly reduced TNF-α levels in immune cells relevant to multiple sclerosis, suggesting potential for immunomodulatory effects.

This study found that Asiasari radix extract may reduce hyperalgesia in mice by modulating NMDA and GABAA receptor activities without affecting cyclooxygenase activity.

This review discusses the influence of androgens on opioid-mediated effects and calls for further research into their role in sex differences and potential therapeutic options for chronic pain and substance use disorders.

This systematic review found that interventions targeting neuropeptides and neurotransmitters, particularly melatonin, substance P, and oxytocin, show consistent evidence for anti-inflammatory, reparative, and psychodermatologic benefits, highlighting the potential of neurohormonal signaling as a therapeutic target in dermatology.

This study found that sebocytes in human skin express and secrete certain adipokines, suggesting they might play active roles in skin inflammation rather than just being targets.

This review examines the potential role of odorant receptors in human skin cells responding to flavor compounds and their implications for skin health and disease, without providing new clinical results.

The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.

This laboratory study concluded that TRPA1 and TRPV1 channels do not play a role in mechanotransduction processes in slowly adapting type II mechanoreceptors in isolated rat sinus hair follicles.

This review summarizes preliminary evidence suggesting that CBD-containing sunscreen may offer UV protection through antioxidant properties, though further studies are needed to confirm safety and efficacy.

This study found a negative correlation between dietary monoene levels, particularly oleic acid, and the capacity for PGE₂ synthesis in rat skin, with the most severe skin issues noted in those fed Zephyr rapeseed oil.

In this study, researchers found that in late pregnancy, the neuroactive progesterone metabolite allopregnanolone inhibits HPA axis responses to immune challenges via an opioid-mediated mechanism.

This review discusses plant-based alternatives to retinoids for dermal antiaging and hair health, highlighting roles for cytokinins and phytoestrogens and reports no new results.

In this study, calcium imaging in transgenic mice revealed that non-neuronal TRPV4 in the skin enhances afferent signaling during electrical stimulation, suggesting a role for neuroimmune interaction in acupuncture signal initiation.

This commentary discusses the potential of natural volatiles in medical aromatherapy, highlighting their ability to synergize with other drugs and modulate biological processes, but reports no new results.

The authors concluded that newly synthesized N-acyl-L-tryptophanyl-isoleucine amides showed high anxiolytic activity in animal models, comparable to diazepam, through interaction with the TSPO receptor.

This study demonstrated that benzothiazepines, such as diltiazem and JTV-519, exert anxiolytic-like effects through allopregnanolone biosynthesis in mice, similar to carbamazepine.