96 citations
,
March 2007 in “Developmental biology” This study found that the Wnt inhibitor Dkk4 may play a role in regulating hair follicle development through a feedback loop with canonical Wnt signaling pathways.
88 citations
,
July 2008 in “Development” This study shows that BMP2 and BMP7 play complex, necessary roles in feather development by regulating dermal condensation formation, with BMP7 acting early as a chemoattractant and BMP2 halting cell migration.
45 citations
,
August 2018 in “Stem Cells International” This article reviews the potential of adipose-derived and Wharton’s jelly stem cells in alopecia treatment but presents no new clinical findings, highlighting their potential benefits and limitations in regenerative medicine.
14 citations
,
December 2016 in “PloS one” This study found that Keratin 26 is expressed differently in hair follicle phases, particularly during catagen and telogen, influencing cashmere growth and interacting antagonistically with the BMP signaling pathway.
11 citations
,
May 2024 in “Reproductive Biology and Endocrinology” In this study, researchers found that human ovaries at different life stages biosynthesize both canonical and non-canonical steroid hormones, with fetal ovaries showing higher enzyme activity related to estradiol and testosterone conversion compared to adult tissues.
10 citations
,
November 2008 in “Veterinary Dermatology” In this study, the misshaped and hairy ear phenotype in mutant mice was linked to mis-expression of certain Hoxc genes due to a chromosomal inversion.
9 citations
,
November 2022 in “Biology” This study identified key genes and pathways related to wool follicle development in coarse wool lambs, suggesting epigenetic factors may influence wool sheep domestication and breeding.
8 citations
,
May 2019 in “Journal of Stem Cells & Regenerative Medicine” This study found that mesenchymal stem cells derived from dental pulp and adipose tissue have distinct gene expression signatures that suggest potential target diseases for clinical applications.
7 citations
,
January 2023 in “Frontiers in Cell and Developmental Biology” This review provides a comprehensive overview of apoptosis-related molecules in head development, highlighting caspases' roles and associated abnormalities in tissues like the brain, sensory organs, skin, and bones, without reporting new results.
7 citations
,
April 2013 in “Animal Production Science” This study found that manipulating maternal cortisol levels during pregnancy altered Merino sheep wool characteristics, increasing fibre length and reducing crimp frequency in the offspring.
6 citations
,
January 2015 in “Journal of regenerative medicine & tissue engineering” This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.
5 citations
,
September 2022 in “Antioxidants” This study found that the clionasterol-rich hexane fraction of Caulerpa racemosa may protect against particulate matter-induced skin damage by reducing oxidative stress and mitochondrial-mediated apoptosis in human keratinocytes and zebrafish.
2 citations
,
December 2025 in “Annals of Medicine” This review discusses the complex correlation between cellular senescence and PCOS, emphasizing senescence markers, mechanisms, and potential anti-senescence therapies, but reports no new clinical results.
1 citations
,
December 2023 This study explored the complex developmental processes of human hair, emphasizing the intricate interactions required for hair follicle morphogenesis and its implications for drug incorporation and concentration interpretation, particularly in early childhood.
1 citations
,
July 2023 in “Communications biology” In this study, researchers found that deleting Med1, a key epigenetic regulator in dental epithelia, led to hair growth on mouse incisors by altering enhancer landscapes and causing a switch from dental to hair lineage transcription programs.
1 citations
,
June 2014 in “Journal of developmental biology” This study found that retinoic acid induces epidermal transdifferentiation into mucosal epithelium in both chick and mammalian embryonic skin, involving specific gene expressions and pathways.
May 2026 in “The EMBO Journal” This study demonstrated how cellular flows and tissue mechanics guide the topological transformations in avian skin, essential for feather follicle development from scales.
January 2022 in “Springer eBooks” This review discusses the potential of the hair follicle dermis to direct hair development and explores concepts related to hair growth and androgenetic alopecia, without reporting new clinical results.
December 2021 in “Journal of clinical images and medical case reports” This review compares mesotherapy and PRP for hair loss but reports no new clinical results; the authors highlight the need to understand their differences for optimal treatment choices.
354 citations
,
February 2011 in “Genes & Development” This study found that abolishing H3K27me3 in mouse skin by targeting Ezh2 and Ezh1 affects hair follicle development and epidermal behavior, revealing functional differences between these tissues.
37 citations
,
January 2009 in “Sexual Development” This study found that chronic exposure to fadrozole or finasteride during frog development induced intersex individuals, which displayed different gene expression profiles depending on the chemical used.
25 citations
,
November 2020 in “Proceedings of the National Academy of Sciences” This study found that the HoxC gene cluster plays a critical role in the development of ectodermal organs, including hair and nails, with mammalian-specific enhancers increasing transcription levels during development.
25 citations
,
November 2020 in “Cell Reports Medicine” Developing human skin has immune cells with memory-like features.
18 citations
,
March 2015 in “Journal of Investigative Dermatology” In this study, silencing BMAL1 and PER1 genes increased melanogenic activity in follicular and epidermal melanocytes, suggesting that peripheral circadian clocks may regulate melanin pigmentation.
11 citations
,
October 2007 in “Journal of Investigative Dermatology” Mutations in the Sgk3 gene cause fuzzy hair in mice.
7 citations
,
October 2015 in “Experimental dermatology” This study found that topical MR blockers alongside glucocorticoids may limit glucocorticoid-induced skin atrophy, suggesting MR's significant role in skin-related endocrinology.
4 citations
,
September 2016 in “World Rabbit Science” This study observed that gene expression differences in Rex rabbits with varying wool densities suggest the involvement of specific genes and signaling pathways, including Shh and Eph, in hair follicle development.
2 citations
,
May 2022 in “International journal of molecular sciences” This study found that the methylation level at CpG III site 4 of the KRT17 gene promoter significantly influences wool production in Angora rabbits, suggesting its potential as an epigenetic marker for breeding high wool yield.
2 citations
,
February 2022 in “Human Gene Therapy” This study found that upregulated miR-149 restricted hair follicle stem cell differentiation and hair growth by inhibiting the MAPK1/ERK2 pathway, which affects FGF2 and c-MYC expression.
In this study, Fgf20 was found to trigger movement and morphogenesis in dermal fibroblasts, facilitating dermal condensate formation essential for hair follicle development.