Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review suggests that, among non-hormonal treatments for menstrual irregularities in adolescents with PCOS, metformin is the most effective and cost-efficient option, particularly in overweight adolescent girls.

This study found that combining fructose and DHT in rats successfully mimicked the clinical phenotypes of non-lean PCOS, providing a novel rodent model for this condition.

This study investigated the molecular mechanisms of hair follicle morphogenesis in Ordos fine-wool sheep, identifying differential genes related to primary and secondary hair follicles, and providing important insights for improving wool quality and breeding strategies.

In this source, recent single-cell RNA-sequencing advances reveal significant transcriptional heterogeneity among skin fibroblasts, and the discussion focuses on the distinct subtypes' roles in skin homeostasis, repair, and their evolution in fibrotic diseases like keloid scars and cancer.

This report on individuals with AEBP1-related classical-like EDS confirmed previous findings and identified hair loss as a potential characteristic feature of this rare condition for the first time. Additionally, cardiovascular complications observed in some individuals suggest that cardiovascular monitoring may be necessary.

This study found that PBMCsec has anti-fibrotic effects on mouse and human skin scars by regulating pro-fibrotic gene expression and inhibiting myofibroblast differentiation and elastic fiber breakdown.

In this study, researchers found that hair follicles and dermal fibroblasts, including dermal papilla cells, supported sustained hair growth in transplanted murine models, with RNA-seq analysis revealing active signaling pathways and gene expression patterns.

This review highlights the potential of ellagic acid for treating various skin conditions due to its antioxidant, anti-inflammatory, and depigmenting properties, but notes that novel formulations are needed to overcome its poor solubility and skin permeability to enhance clinical efficacy.

This review discusses the role of the ectodysplasin A2 receptor as a biomarker and driver of ageing related to inflammation, and its potential therapeutic implications, but reports no new clinical findings.

This review discusses the evolution of adipose tissue research in regenerative medicine, from tissue transfer to cell-free bioengineering applications, highlighting its therapeutic potential, current limitations, and future directions.

This study found that patients with alopecia areata had significantly higher serum IL-1R1 levels, IL-1R1 gene expression, and hsa-miR-19b-3p levels compared to healthy controls, suggesting these could serve as diagnostic and prognostic markers for the disease's severity.

This study found that combining excimer light at 308 nm with tacrolimus 0.1% was more effective in treating alopecia areata of the scalp compared to excimer light alone, as indicated by a greater reduction in the SALT score and better improvement in Treg function.

This review summarized the latest knowledge suggesting that Janus kinase inhibitors may have therapeutic potential for treating skin diseases like atopic dermatitis and psoriasis, especially when conventional therapies do not work.

This study observed that women with Polycystic Ovary Syndrome, particularly those with specific phenotypes, had a significantly higher risk of developing kidney stones compared to healthy controls.

This case report discusses a 56-year-old female patient with multiple risk factors, including diabetes mellitus and liver cirrhosis, who developed necrotizing fasciitis, emphasizing the complexity and high cost of treatment required.

This review discusses factors affecting thyroid function and Hashimoto's thyroiditis, mentioning treatment options, but reports no new clinical findings; the need for nutrient consideration is emphasized.

This review discusses key molecular targets in cosmetic research and reports no clinical results; it highlights the role of telomerase, sirtuins, and tyrosinase in anti-aging and depigmentation strategies.

This study found that in stretch-mediated tissue expansion, fibroblasts adopt an embryonic-like, low-collagen state that enhances epidermal stem cell renewal, supporting coordinated skin expansion crucial for reconstructive surgeries.

In this study, researchers developed vegan exosome-like vesicles from microalgae that mimic mammalian exosomes, demonstrating promising in vitro, ex vivo, and clinical effects such as improved wrinkle depth and elasticity, making them a potential alternative in cosmetic applications.

This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.

The researchers presented a case study on Exo.Reset®, a cosmetic formulation using extracellular vesicle technology, demonstrating systematic application of recognized standards to ensure scientific rigor and regulatory compliance in skin rejuvenation product development, providing a practical model for EV-based cosmetic innovations.

This study investigated the photoprotective properties of Brazilian pepper tree extract against UV-induced damage in skin cells, reporting that it enhanced expression of genes relevant to skin health and showed superior activity compared to standard antioxidants.

This systematic review synthesizes evidence from the past 20 years to highlight the potential of exosome-based therapies from stem cells and plants in improving cutaneous repair, skin aging, and challenging dermatological conditions through mechanisms like immunomodulation and collagen remodeling.

This study highlights the critical role of mitochondria in skin aging and wound repair, suggesting that targeted interventions such as antioxidants, NAD⁺ boosters, and NRF2-based therapies may enhance mitochondrial function and improve cutaneous health.

This study examined dermal papilla cells from hair follicles, finding that gene expression changes linked to wound healing and stem cell activity align with hair follicle regression, which could inform strategies for hair growth and skin rejuvenation.

This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.

This review discusses the potential topical benefits of cannabidiol in dermatology and cosmetics, highlighting its diverse effects and therapeutic roles but reports no new clinical results, emphasizing the need for further research.

This review found that LED therapy, using light in specific wavelengths, may offer effective, non-invasive treatment options for various skin conditions, including acne, melasma, photoaging, and wound healing.

This review highlights concerns about dermatological side effects linked to rapid weight loss from glucagon-like peptide-1 receptor agonists used for type 2 diabetes and obesity treatment, such as skin laxity, decreased collagen, and hair loss, emphasizing the importance of managing these while retaining metabolic benefits.

In this study using a mouse model, researchers utilized single-cell RNA sequencing to create a comprehensive cellular atlas of infected versus uninfected wounds, revealing that Enterococcus faecalis infections lead to immunosuppressive changes in skin cells and disrupt normal wound healing processes.