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Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Certain drugs that block specific enzymes can help treat prostate diseases.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Choline and biotin are important for liver health and preventing certain deficiencies in animals, and more research is needed to understand their benefits in humans.

A certain medication improved severe itching in a boy with liver and bowel disease by reducing histamine levels, suggesting a new treatment target.

Finasteride affects brain stress and enzyme activity differently in various regions, possibly helping with liver-related brain issues.

Finasteride is a safe, effective treatment for hirsutism with fewer side effects.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.

The safety of placental and umbilical extracts in cosmetics is uncertain, requiring more research.

Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

HSL treatment speeds up hair growth and reduces oxidative stress in hair follicles of ob/ob mice.

PCOS in lean women is a serious health condition with implications beyond fertility, affecting metabolism and increasing cardiovascular disease risk.

Finasteride in male rats causes liver and metabolic issues in their offspring.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Rutin may help treat symptoms of polycystic ovary syndrome (PCOS) in rats.

Some acne medications have side effects; doctors should educate patients and may not need to do frequent lab tests for all.

Indian Gooseberry has potential for cancer prevention and treatment and promotes hair growth.

Skin and hair changes in horses can indicate serious diseases, and recognizing these signs is important for treatment and management.

Women with PCOS face many health risks, but exercise, a healthy diet, and weight management can help.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Gene mutations can cause problems in male genital development.