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A Holstein calf in Iran with a severe genetic skin disorder was euthanized due to incurable symptoms.

Caffeine intake during pregnancy and lactation can cause skin lesions in mother rats and their babies, not linked to cortisol levels.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

Women with acne and irregular periods had higher active testosterone levels, which could suggest the usefulness of antiandrogen treatment.

Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.

One cat with low thyroid hormone had growth issues, and another with high thyroid hormone had skin problems; both got better with treatment.

Some blood-thinning medications can increase the risk of bleeding, and certain factors like genetics and other health conditions affect their safety and effectiveness.

Obesity and bariatric surgery can cause hair thinning and temporary hair loss due to nutritional deficiencies and stress.

Fat tissue under the skin affects hair growth and aging; reducing its inflammation may help treat hair loss.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

Higher miR-34a levels and the A variant of the MIR-34A gene are linked to increased risk and severity of alopecia areata.

The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.

Finasteride reduces prostate size and PSA levels in young patients.

SAHA syndrome is a condition in women involving skin and hair issues, often related to hormonal imbalances, and is treated based on the underlying cause.

Severe hair loss links to metabolic issues in older men with psoriasis.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Injectables can feminize or masculinize a transgender person's face, but more research is needed for best practices.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.

Pediatric dermatologists need to understand the unique skin health needs of LGBTQIA youth to provide better care.

Some conditions mimic PCOS symptoms and need careful diagnosis to treat potentially serious health issues.

PCOS is a complex disorder managed by treating symptoms and requires a team of specialists.

Too much male hormone is the main cause of Polycystic Ovary Syndrome.

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

The document concludes that reactivation of herpesviruses, especially HHV-6, is linked to severe symptoms and complications in drug-induced hypersensitivity syndrome.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.