Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study demonstrates that massage significantly enhances the follicular targeting of dutasteride-loaded nanocapsules, increasing drug accumulation in hair follicles by up to 5 times.

In this study, researchers found that ligand homodimerization controls the receptor binding specificity of the FGF9 subfamily, preventing off-target activation of FGFR "b" isoforms.

Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.

This study found that the HPCH-based formulation P-08–016 may facilitate finasteride deposition in the dermis, potentially offering an alternative to systemic therapy by minimizing systemic absorption.

This review discusses the potential of nanotechnology-based formulations for delivering topical minoxidil to improve hair loss treatment outcomes and reports no new clinical results, urging further research into their benefits and safety considerations.

In this study, an injectable hydrogel incorporating antibacterial agents was shown to effectively heal wounds and promote hair follicle and capillary regeneration, offering a promising approach for skin tissue engineering.

This study found that abietic acid from pine resin more effectively inhibits testosterone 5α-reductase than several plant extracts, suggesting potential for treating androgen-dependent diseases.

This review discusses the enhanced permeability and retention (EPR) effect as a mechanism for targeted drug delivery in cancer therapy and reports no new clinical results.

This study developed a portable electrospinning device that mimics hair for cosmetic thickening in a mouse model, showing performance comparable to benchtop models with added safety and cost benefits.

This overview discusses advancements in the understanding of molecular genetics in heritable keratinization disorders, focusing on recent cases of inherited ichthyosis, and reports no new clinical results.

This study reports that Ca 2+ binding alters the dynamics and surface properties of PKD-like domains in Clostridium histolyticum collagenases, enhancing their stability and potentially aiding in collagen-targeting vehicle development.

This study found that compounds 21–23 and 25 exhibited strong 5α-reductase II inhibition in vitro and significantly reduced rat prostate weight, performing comparably to finasteride.

This study developed a niosomal delivery system loaded with tretinoin and bicalutamide, optimized for follicular targeting in acne management, showing promising accumulation in hair follicles in animal models.

This study found that micro-current electrical stimulation may promote hair growth in human hair follicle-derived papilla cells and a mice model by enhancing cell proliferation, migration, and activating key growth pathways.

This study found that formulation factors like pH, viscosity, and chemical enhancers can significantly influence intrafollicular hydrocortisone permeation in vitro, with higher pH and enhancers reducing follicular contribution.

This study found that novel RNA aptamers specifically inhibited FGF5-induced cell proliferation, suggesting their potential as candidates for treating FGF5-related diseases or hair disorders.

This case report describes a patient with breast cancer who developed female androgenetic alopecia after starting tamoxifen therapy.

In this study involving a mouse model, researchers reported that intranasal delivery of protein-based CRISPR/dCas9 nanoparticles targeting the gene *Sirt1* reduced cerebral edema and increased survival following ischemic stroke, with no significant toxicity observed.

In this study, applying deer antler velvet extract-loaded niosomes and microspicules serum to the scalp significantly improved hair growth, melanin content, and skin hydration over 14 to 30 days without causing skin irritation.

This study presents recombinant human hair keratins K31 and K81, observing novel nanostructures from their self-assembly and emphasizing disulfide crosslinking's role in this process.

This study developed solid lipid nanoparticles for effective delivery of shRNA-encoding plasmids, showing reduced 5α-reductase levels in DU-145 cells without significant cytotoxicity.

In this study, researchers suggest that strategic early intervention during fetal wound healing could lead to significantly improved long-term skin regeneration outcomes.

This review examines current and potential approaches to managing chronic wound inflammation through macrophage-targeted strategies using ECM-inspired wound dressings, but it reports no new clinical results.

This study concluded that while home-based intense pulsed light, laser diodes, radiofrequency, and light-emitting diode devices are recommended for certain skin conditions, ultraviolet B phototherapy for psoriasis showed mixed evidence compared to clinic treatments.

This animal study found that intravenous administration of anionic squarticles, a lipid nanoemulsion, increased survival rates in rats with amitriptyline overdose by mitigating adverse effects and restoring normal blood pressure, highlighting its potential as a detoxifying antidote.

In a double-blind clinical trial, this study found that a gel containing chitosan-coated spironolactone nanoparticles effectively reduced acne lesions over 8 weeks without adverse skin effects, suggesting potential for enhanced acne treatment through targeted skin delivery.

Blocking adenosine A2B receptor may prevent or treat hearing loss.

This study explored using a chitosan oligomer coating for topical delivery of dutasteride-loaded nanostructured lipid carriers, aiming to reduce systemic exposure and cytotoxicity.

This study observed that silver nanoparticles synthesized using Laurus nobilis leaf extracts significantly inhibited protein denaturation and membrane stabilization in vitro, suggesting potential as a basis for novel antiarthritic drugs.

LLLT is a safe, promising hair loss treatment, but more research needed.