57 citations
,
February 2013 in “Journal of Dermatological Science” This article reviews methods to enhance epithelial–mesenchymal interactions for hair follicle bioengineering but does not present new experimental results; it emphasizes optimizing combinations for successful regeneration.
48 citations
,
September 2017 in “Frontiers in Bioscience” This review explores the role of nanotechnology in wound healing, highlighting its potential through antimicrobial properties, selective inflammatory action, angiogenesis promotion, and its use in drug and gene delivery.
46 citations
,
March 2019 in “Journal of Pineal Research” The study found that melatonin treatment in early postnatal cashmere goats increased both the quantity and quality of cashmere by promoting secondary hair follicle development and enhancing antioxidant enzyme activities.
36 citations
,
September 2009 in “Journal of Cellular and Molecular Medicine” This review addresses the role of skin-resident adult stem/progenitor cells in skin homeostasis, disease, and cancer development, and reports no new research results.
26 citations
,
March 2018 in “Dermatology and Therapy” This study found that conditioned media from epidermal progenitor cells improved skin aging signs in a clinical trial and protected fibroblasts from oxidative stress in vitro.
19 citations
,
August 2019 in “Seminars in Plastic Surgery” This review explains the biology and preparation of platelet-rich plasma and discusses its clinical applications in plastic surgery, but reports no new findings.
17 citations
,
January 2014 in “Stem Cells Translational Medicine” This study reports that epidermal neural crest stem cells from dogs (cEPI-NCSC) can generate neural crest derivatives and may offer a new cell-based therapy for canine spinal cord injury, with potential as a model for human treatments.
12 citations
,
February 2013 in “The Open Stem Cell Journal” This article reviews the definitions, opportunities, advantages, and limitations of dental pulp stem cells and stem cells from human exfoliated deciduous teeth in tissue engineering and regenerative medicine, reporting no new clinical results.
10 citations
,
September 2020 in “Archives of Dermatological Research” Both methods improve hair density and thickness; double-spin may be more effective.
8 citations
,
May 2021 in “Bioengineering & translational medicine” This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.
7 citations
,
April 2012 in “Biomolecular concepts” This article reviews the role of keratins in epithelial function and structure, discussing their involvement in growth control, organelle functions, and pathomechanisms of disorders, but reports no new clinical results.
6 citations
,
January 2018 in “Journal of Cellular Physiology” In this study, adipose-derived stem cells from human scalp were successfully directed towards chondrocyte differentiation, with TGF-beta3 and BMP-6 growth factors proving effective for in vitro chondrogenesis.
4 citations
,
February 2020 in “Cell & tissue research/Cell and tissue research” This study suggests that adult hair follicle stem cells can survive and potentially differentiate into neuronal cells after being transplanted in a mouse model of traumatic brain injury, indicating promise for TBI therapy.
3 citations
,
July 2024 in “Annals of Biomedical Engineering” This study found that multiphoton microscopy imaging allows for detailed observation and quantitative analysis of collagen alterations in the progression of endometrial cancer, potentially offering a faster, more accurate method for early diagnosis compared to current protocols.
1 citations
,
October 2025 in “International Journal of Nanomedicine” This review explores the potential for using exosomes in treating autoimmune skin diseases and promoting skin regeneration, highlighting current applications, delivery methods, and ongoing clinical trials while also identifying challenges and future research directions within dermatology.
1 citations
,
January 2024 in “Theranostics” This source reviews the role of exosomes in regenerative medicine, highlighting their ability to mediate cell communication and transport biomolecules to enhance or impair biological functions, with potential applications in tissue repair and regeneration.
1 citations
,
January 2023 in “In vivo/In Vivo” This study suggests that the activation of box A in mesenchymal cell models may enhance stem cell properties, increasing the expression of stemness markers like OCT4, NANOG, and SOX2.
May 2026 in “The EMBO Journal” This study explores the complex mechanisms of skin aging, including cellular senescence and disrupted communication, and highlights rejuvenation strategies like gene expression rewiring and microbiome modulation, offering potential frameworks for regenerative therapies and precise interventions in skin and systemic aging.
May 2026 in “Organoid Research” This review discusses recent advancements in hair follicle organoid technology for alopecia treatment but presents no new experimental results, emphasizing the potential for clinical applications and drug screening.
February 2026 in “Frontiers in Medical Technology” This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.
This review reports that hair follicles are dynamic neuro-immuno-endocrine organs with intrinsic signaling pathways, which play a crucial role in hair disorders like alopecia. It highlights emerging regenerative approaches targeting these pathways for hair restoration.
November 2025 in “Frontiers in Immunology” This review discusses the role of immune cells in the pathogenesis of alopecia areata and highlights emerging immunomodulatory strategies and novel therapeutic targets aimed at offering more effective and durable treatments for this autoimmune hair loss disorder.
In this review study, researchers examined existing literature on regenerative medicine and stem cells for androgenetic alopecia and highlighted potential new therapeutic techniques for hair regrowth, emphasizing stem cells' impact on prognosis.
This randomized control trial reported that mesenchymal stem cell-derived exosomes significantly increased hair density and thickness in patients with androgenic alopecia, with a mean increase of 35 hairs/cm² over 12 weeks compared to the placebo group, which showed minimal hair density changes.
April 2023 in “Digital Library of Theses and Dissertations (Universidade de São Paulo)” This study concluded that mesenchymal stem cells from adipose tissue harvested using laser-assisted liposuction with selective photo-stimulation are as effective and low-risk for cell therapy as those obtained through conventional liposuction, based on their differentiation potential, cellular proliferation, and cytokine expression.
The study found that adipose-derived mesenchymal stem cells obtained via laser-assisted liposuction with selective photo-stimulation are comparable in differentiation potential and tumorigenic risk to those from conventional liposuction for cell therapy applications.
February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that Prss53-mutated rabbits exhibited curved hair and skeletal dyskinesia, suggesting a link between Prss53 loss and these traits, potentially involving disrupted calcium metabolism.
September 2016 in “Springer eBooks” This review discusses the application of mesenchymal stem cells and their secretory factors for skin and hair regeneration and reports no clinical results; the authors highlight the progress and call for practical applications.
January 2015 in “Springer eBooks” This chapter reviews the potential of adipose-derived stem cells for skin aging and hair loss treatments but reports no new experimental results; the authors highlight these stem cells as a promising regenerative resource.
August 2014 in “Warwick Research Archive Portal (University of Warwick)” This study found that obesity in women may impair endometrial stromal function and contribute to reproductive complications, possibly due to metabolic influences rather than immune cell differences.