Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

Hair graying is caused by the loss of pigment cells due to poor maintenance of stem cells in the hair follicle.

In this study using transgenic mice, activating P-catenin signaling induced new hair follicle formation and maintained follicle tumors, with implications for understanding skin homeostasis.

This study observed that exposure to heavy metal salts affected skin and hair morphology in mice, with lead acetate decreasing keratinocyte proliferation and zinc sulfate and sodium dichromate increasing it.

This study found that ectopic expression of the lymphoid-enhancer factor can induce K17 protein in the skin, suggesting a link between skin development and wound repair processes in mice.

This study demonstrates that mice with ectopic expression of the human GLI-1 gene in their skin developed tumors resembling human basal cell carcinoma, suggesting that GLI-1 is central to tumor development without additional p53 or Ha ras mutations.

This study found that using ectopic expression of CD24 is a promising approach for selecting genetically modified human epidermal stem cells for safe cutaneous gene therapy in cancer-prone conditions.

This study found that over- and ectopic-expression of FoxN1 in early life negatively affected the development of thymic epithelial cells, T and B cells, and skin epithelial cells.

In this study, ectopic Wnt10b-mediated β-catenin activation in hair follicles resulted in larger regenerating anagen hair structures, an effect modulated by the Wnt inhibitor DKK1.

This case report highlights a rare instance of severe multi-organ involvement following a single dose of methotrexate for ectopic pregnancy, requiring intensive care but ultimately successfully treated with leucovorin and supportive care.

In this study, forced expression of the transcription factor cDermo-1 in chicken dermis led to the formation of ectopic feather buds and enhanced feather growth, demonstrating its role in initiating skin appendage development.

Two studies in Cell Stem Cell reported that human and mouse somatic cells can be reprogrammed into induced pluripotent stem cells using microRNAs, eliminating the need for ectopic protein expression.

This case study reports the first known instance of hepatic adrenocortical carcinoma in a virilized young woman, highlighting the importance of comprehensive evaluation to identify ectopic adrenal tumors.

This study found that targeting connective tissue sheath contraction with an MLCK inhibitor may improve hair growth in androgenetic alopecia by reducing premature hair regression caused by ectopic apoptosis of hair follicle progenitor cells.

This study found that Sonic hedgehog signaling is crucial for Merkel cell development around hair follicles in mice, with Polycomb repressive complex 2 loss causing ectopic Merkel cells across all hair types.

This study found that inducing Atoh1 expression in transgenic mice is sufficient to generate new Merkel cells in the epidermis, with variations by skin location, developmental age, and hair cycle stage.

A rare skin growth was successfully removed without recurrence after one year.

This study found that manipulating Wnt signaling pathways in cutaneous wounds can induce skin structures resembling regeneration, suggesting a potential role for Wnt signals in restoring skin architecture during wound healing.

This article proposes that alopecia areata may be caused by immune attacks on hair follicles after an immune privilege collapse, suggesting new therapeutic approaches targeting this immune response pattern.

This study identified a 195 bp duplication in crested chickens that causes large crest feathers and can be associated with cerebral hernia in some breeds, but not all.

This case report highlights that women with nonclassical congenital adrenal hyperplasia should be aware of the risk of having a child with classical CAH if their partner also carries a severe mutation.

This article comments on Nemet et al.'s study of blepharitis, emphasizing that Demodex folliculorum is a significant factor in its associated morbidity and can be effectively managed with tea tree oil shampoo.

This study found that modulating BMP activity in transgenic mice affects the development and characteristics of several ectodermal organs, such as skin, hair, and claws, highlighting a stage-dependent influence on organogenesis.

This study demonstrates that hair follicle bulge stem cells can transition into other stem cell compartments, indicating their role in maintaining both hair follicles and sebaceous glands.

This study found that nevoid basal cell carcinomas originate in the epidermis and upper hair follicles, resembling early nonnevoid basal cell carcinoma proliferations.

This study indicated that abnormal Bmp signaling in β-catenin gain-of-function mutants is associated with anorectal malformations, shedding light on potential mechanisms underlying these congenital conditions.

In this mouse study, researchers found that the absence of laminin-511 in skin delays hair follicle development and disrupts hair shaft differentiation, affecting key transcription factors for hair keratins.

In this study, transiently activating the sonic hedgehog signaling pathway in chickens transformed reticulate scales on the feet into feathers comparable to body feathers, without ongoing treatment, suggesting this pathway affects the diversity of bird skin appendages.

This report explores the potential cellular origins of keratoacanthoma lesions on the oral mucosa, noting that it reports no new results.

In this study, researchers found that cyclophosphamide treatment unexpectedly reduced splenic melanin deposition in a murine model, whereas this effect was down-regulated more by the normal and dystrophic catagen phase of the hair cycle.

This study found that specialized nipple epidermis in mice is maintained by the repression of TGFβ signaling through estrogen, which highlights the role of hormonal regulation in epidermal maintenance.