21 citations
,
January 2023 in “International Journal of Molecular Sciences” This review discusses the role and interactions of the calcium-binding protein S100A6 in cellular processes and its association with various diseases, highlighting the need for further research to fully understand its biological impact.
4 citations
,
September 2025 in “International Journal of Molecular Sciences” This review discusses the dermatological applications and potential health benefits of Epigallocatechin-gallate (EGCG) from green tea, but provides no new clinical findings.
January 2025 in “Applied Sciences” This review examines sulforaphane's interactions with hormone-mediated health conditions, focusing on gender-specific health issues, but reports no new original research findings.
346 citations
,
April 2020 in “Frontiers in Oncology” This review discusses the roles of key epithelial-mesenchymal transition factors and potential therapeutic opportunities involving cancer metabolic pathways, reporting no new clinical results.
175 citations
,
January 2020 in “European Journal of Endocrinology” These guidelines recommend testing thyroid function in patients with obesity due to common hypothyroidism, and highlight that weight loss is crucial for addressing hormonal imbalances, with only modest weight loss benefits from treating endocrine disorders.
100 citations
,
November 2017 in “EMBO Reports” This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.
91 citations
,
December 2019 in “The EMBO Journal” This study found that the E3 ligases NEDD4 and NEDD4L regulate intestinal stem cell priming by degrading the LGR5 receptor, and their loss leads to increased Wnt activation and crypt proliferation, which in turn accelerates intestinal tumor progression in mice.
63 citations
,
November 2012 in “Journal of Cellular Biochemistry” This paper discusses the role of Runx1 in epithelial biology and pathology, highlighting its dual function as a tumor promoter and suppressor in different contexts, and reports no new experimental findings.
59 citations
,
August 2021 in “Frontiers in Endocrinology” This review discusses the roles and therapeutic effects of GLP-1 receptor agonists on the nervous, cardiovascular, and endocrine systems, but reports no new clinical results, emphasizing the need for further research on their impact on metabolism and tumor relationships in type 2 diabetes patients.
44 citations
,
April 2023 in “Genes & Diseases” This review discusses the paracrine function of mesenchymal stem cells in tissue regeneration and repair, focusing on secreted bioactive substances and their role under different microenvironments; it reports no new clinical results.
40 citations
,
September 2024 in “Heliyon” This review discusses the role of bioceramics, highlighting their bactericidal activity, lack of side effects, and ability to release metallic ions for hard and soft tissue repair. The authors suggest that integrating bioceramics with other biomaterials could offer a cost-effective, efficient alternative for wound healing.
22 citations
,
July 2015 in “PloS one” This study found that Foxp1, a transcriptional factor, plays a key role in regulating hair follicle stem cell proliferation by modulating oxidative stress and the cell cycle during hair growth phases.
21 citations
,
May 2022 in “Frontiers in Cell and Developmental Biology” This review covers the structure, development, cycle, and molecular regulation of hair follicles but does not report new results, aiming to offer insights for addressing hair follicle-related diseases.
13 citations
,
February 2023 in “Biology” This review highlights the potential of cell-free therapies, particularly cell extracts, in addressing radiation-induced salivary gland damage from head and neck cancer treatment, emphasizing their practicality and safety compared to traditional therapies despite incomplete understanding of their bioactive components.
11 citations
,
January 2020 in “Medical Journal Armed Forces India” This review discusses the various aspects of insulin resistance and highlights its potential evolutionary benefits, reporting no new experimental findings.
4 citations
,
July 2025 in “International Journal of Molecular Sciences” This review discusses Amphiregulin (AREG) as a potential target for treating fibrotic disorders and cancer, highlighting its role in disease progression and promising results in preclinical studies and early trials.
4 citations
,
October 2022 in “Nutrients” This review discusses the impact of lifestyle interventions, including diet and probiotics, on weight and metabolic health in women with PCOS, but reports no new clinical results.
3 citations
,
July 2025 in “Obesity Facts” This review examines how GLP-1 receptor agonists might impact metabolic and reproductive outcomes in polycystic ovary syndrome, but it reports no new clinical findings and highlights the need for further research.
3 citations
,
May 2025 in “Clinical Endocrinology” Evaluate and manage androgen excess in women with a systematic approach, considering both physical and psychological impacts.
3 citations
,
November 2024 in “Egyptian Journal of Medical Human Genetics” This bibliometric analysis identified SGK1 as a key factor in cancer, showing that its dysregulation can lead to tumor growth and treatment resistance. The authors highlighted SGK1's potential as a therapeutic target, but note that further research is needed to develop effective treatment strategies.
3 citations
,
March 2023 in “International journal of molecular sciences” This review discusses the patterns and regulatory mechanisms of keratin expression in various biological conditions and reports no new experimental results.
2 citations
,
August 2022 in “Frontiers in Veterinary Science” This study constructed a ceRNA regulatory network related to cashmere goat secondary hair follicle development, highlighting the role of circRNA in their morphogenesis through the ceRNA mechanism.
1 citations
,
May 2025 in “Cell Reports Medicine” This study found that RSPO1, a Wnt/β-catenin pathway agonist, significantly induces insulin-producing β cell replication and neogenesis in various settings, offering a promising potential therapy for diabetes.
1 citations
,
February 2017 in “Journal of gynecology and womens health” This review discusses the causes and management of hirsutism, recommending low-dose oral contraceptives with flutamide over cyproterone-containing preparations, but reports no new clinical findings.
January 2026 in “Therapeutics” This study found that SCUBE3 protein is upregulated in various cancers, promoting tumor growth and poor outcomes, while suppressing growth in renal cell carcinoma, and may serve as a diagnostic marker and potential therapeutic target for several diseases due to its secreted nature.
November 2025 in “Preprints.org” This scoping review reports that while empirical evidence suggests an overlap between Long/Post Covid-19 syndrome, chronic fatigue syndrome, and fibromyalgia, the underlying molecular mechanisms remain unclear, highlighting the need for standardized definitions and rigorous methodologies in Long Covid research.
January 2025 in “Case Reports in Endocrinology” This paper discusses four rare causes of hyperandrogenism in women, emphasizing the importance of detailed biochemical testing and invasive diagnostic tools when imaging fails to identify ovarian tumors.
January 2024 in “Medicina” This review examines the pathogenesis of androgen excess and dyslipidemia in PCOS and the potential role of statins as a treatment but provides no new clinical results.
June 2020 in “AACE clinical case reports” This case report illustrates that Leydig cell tumors, despite causing significantly elevated androgen levels, can be difficult to localize due to their small size, as demonstrated in a 42-year-old woman whose tumor was only identified after oophorectomy.
1 citations
,
November 2022 in “International journal of molecular sciences” This study found that local injections of fetal tissue mesenchymal stromal cells in mice significantly improved healing and hair follicle density after high-dose radiation-induced skin damage.