294 citations
,
January 2016 in “Stem Cells International” This review discusses the characteristics, biomaterials, and tissue engineering methods for adipose-derived stem cells in a 3D environment, highlighting their potential in regenerative medicine without presenting new clinical results.
21 citations
,
March 2025 in “Journal of Extracellular Vesicles” This review discusses how using hydrogels as a three-dimensional culture platform for mesenchymal stem cells might affect the production of extracellular vesicles, highlighting challenges in standardization and opportunities to boost EV yield via combined hydrogels and bioreactor methods.
7 citations
,
August 2025 in “Journal of Nanobiotechnology” This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.
3 citations
,
July 2025 in “Gels” This review explores how recombinant protein hydrogels, employing molecular engineering and crosslinking strategies, offer advanced applications in regenerative medicine by mimicking extracellular matrix dynamics and providing enhanced mechanical, environmental, and biological properties.
1 citations
,
June 2024 in “Preprints.org” This review explores the roles of dermal sheath cells in wound healing, highlighting their multifunctional contributions to inflammation, proliferation, and extracellular matrix remodeling, and proposes new insights into tissue regeneration and repair, especially in differentiating between hairy and non-hairy skin sites.
May 2025 in “Antioxidants” This review highlights how natural products with antioxidant properties can modulate the Wnt signaling pathway, potentially influencing various pathological conditions such as cancer, stroke, and regenerative medicine. It also addresses controversies in the compounds' mechanisms across different models and suggests research directions for future studies.
March 2025 in “Frontiers in Cell and Developmental Biology” This study reviewed how neuropeptides and cutaneous innervation play crucial roles in the process of wound healing, suggesting they significantly influence inflammation and tissue repair phases.
January 2025 in “Medicina” This study reviews emerging techniques in acute burn wound therapy, noting innovations such as advanced imaging for better wound assessment and new closure strategies aimed at improving healing, graft survival, and scarring outcomes, while emphasizing the need for further research to validate these methods.
This study found that GPC1 is a key regulator of angiogenesis in hair follicles and may be an interesting target for addressing alopecia in dermatology research.
This study found that GPC1 is a key regulator of angiogenesis in human dermal microvascular endothelial cells, influenced by factors secreted by keratinocytes, and may be a target for alopecia treatment research.
This study found that GPC1 plays a crucial role in regulating angiogenesis in human dermal microvascular endothelial cells, which may make it a potential target in alopecia treatment research.
This study found that GPC1 is a significant regulator of angiogenesis in human dermal microvascular endothelial cells, suggesting its potential as a target for alopecia research.
125 citations
,
March 2017 in “Micromachines” This review highlights recent advancements in microfluidics for 3D tissue model generation and discusses its applications in tissue engineering and high-throughput drug screening without reporting new experimental results.
82 citations
,
July 2022 in “Bioengineering & Translational Medicine” This review examines how biochemical and biophysical induction factors influence cell fate in tissue engineering and reports no new experimental results.
3 citations
,
August 2025 in “Advanced Therapeutics” This review explores advancements in cytokine engineering for regenerative medicine, highlighting the development of modified cytokines with enhanced stability and tissue-targeting, potentially improving treatments for chronic wounds and fibrotic diseases by promoting tissue healing and minimizing inflammation, while adapting concepts from cancer immunotherapy.
14 citations
,
June 2022 in “BMC genomics” This study identified key genes involved in hair follicle development in Merino sheep, offering insights for improving wool production and providing a basis for future breeding programs.
This study explored the molecular communication between hair matrix cells and dermal papilla cells in cashmere goats, revealing key ligand-receptor pairs and signaling pathways that facilitate intercellular crosstalk and potentially influence hair growth mechanisms.
488 citations
,
July 2021 in “Cell” This review discusses the development, lineages, functions, and roles of fibroblasts in fibrosis across four organs, highlighting their capabilities in tissue repair and contributions to fibrotic disorders when aberrantly activated, but it reports no new experimental findings.
294 citations
,
February 2011 in “Cell” Nephronectin helps attach muscle cells to hair follicles.
129 citations
,
July 2019 in “Stem Cell Research & Therapy” This review examines the role of epidermal stem cells in wound healing, discussing their characteristics and mechanisms, but does not report new clinical results.
114 citations
,
February 2023 in “International Journal of Molecular Sciences” This review discusses the relationship between skin microbiome changes and conditions such as ageing and skin disease, emphasizing the need for further research, but reports no new findings.
40 citations
,
September 2024 in “Heliyon” This review discusses the role of bioceramics, highlighting their bactericidal activity, lack of side effects, and ability to release metallic ions for hard and soft tissue repair. The authors suggest that integrating bioceramics with other biomaterials could offer a cost-effective, efficient alternative for wound healing.
28 citations
,
April 2021 in “Biomedicines” This review evaluates in vitro hair follicle models, techniques, and challenges without reporting new clinical results, emphasizing their future potential in hair transplantation.
18 citations
,
January 2022 in “Oxidative Medicine and Cellular Longevity” Fibroblasts are crucial in scar formation and wound healing, with potential therapies aiming for scarless healing.
15 citations
,
March 2021 in “Journal of Nanobiotechnology” This study developed a nanoscale biomimetic matrix that effectively and stably expands human hair follicle stem cells, offering a new tool for hair follicle reconstruction research.
14 citations
,
July 2019 in “Journal of Investigative Dermatology” In this study, targeted inactivation of the integrin-linked kinase gene in melanoblasts led to defects in cell migration, proliferation, and ability to populate the skin, implicating an integrin-linked kinase-Rac1 connection in melanocyte function.
11 citations
,
April 2022 in “International Journal of Molecular Sciences” This review discusses the role of the Wnt/β-catenin pathway in skin wound repair and explores how photobiomodulation may affect chronic wound healing, but it reports no new clinical results.
10 citations
,
May 2025 in “Cell Biomaterials” This perspective highlights how advancements in single-cell sequencing and digital pathology can help understand the complex mechanisms of immune responses, fibrosis, and tissue remodeling related to medical implants, aiming to address the challenges of implant-related tissue reactions reported in this study.
7 citations
,
January 2017 in “Stem Cells International” This review categorizes current research on neural organogenesis and highlights potential future applications for treating central nervous system diseases, but reports no new clinical results.
6 citations
,
May 2025 in “Cosmetics” This review synthesizes research on solar radiation's multifaceted effects on skin and recent advancements in sunscreen technology, including formulation, testing methods, and the use of AI, to inform future sun protection product development.