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TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Different types of skin cells play specific roles in development, healing, and cancer.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Injecting alpha-melanocyte-stimulating hormone in mice improved skin healing and reduced scarring.

Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.

A hydrogel made from pig fat helps wounds heal faster by regenerating skin fat cells.

Mice genetically modified to produce more CD109 in their skin had less inflammation and better healing with less scarring.

Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.

Mouse stem cells from hair follicles can improve wound healing and reduce scarring.

New materials help control stem cell growth and specialization for medical applications.

Different types of fibroblasts play various roles in kidney repair and aging, and may affect chronic kidney disease outcomes.

Low oxygen levels improve the function of hair and skin cells when they are in direct contact.

Inducing ferroptosis in hepatic stellate cells is crucial for treating liver fibrosis.

The skin's dermal layer contains true stem cells with diverse functions and interactions that need more research to fully understand.

The document concludes that a complete skin restoration biomaterial does not yet exist, and more clinical trials are needed to ensure these therapies are safe and effective.

Future research should focus on making bioengineered skin that completely restores all skin functions.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Some medicinal plants can help heal wounds and may lead to new treatments.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Blocking β-catenin in skin cells improves hair growth during wound healing.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Wnt signaling is crucial for skin wound healing and reducing scars.

Nude mice with grafted human skin developed scars similar to human hypertrophic scars.

Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.

Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.

Fat cells are important for tissue repair and stem cell support in various body parts.