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Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.

Women with PCOS have higher androgen levels that decrease with age but are still higher than in women without PCOS.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Young Czech women with PCOS have a higher risk of heart problems and should be regularly checked for cholesterol and glucose issues.

Hair pain is more common in women with hair loss, but it's not linked to the cause or severity of hair loss.

Manage hair shedding by identifying triggers, possibly using supplements or medications, and tracking with a health calendar.

Brazilian women with PCOS and both menstrual irregularity and high male hormone levels have a higher chance of having metabolic syndrome.

Skin organoids are a promising new model for studying human skin development and testing treatments.

Low vitamin D receptor levels found in hair loss patients; topical vitamin D treatment suggested.

Older obese women with PCOS have higher cardiovascular and metabolic risks despite lower androgen levels.

UV light might cause excessive hair growth by increasing PGE2 in the skin.

Feathers are useful for researching growth, regeneration, and the effects of treatments like chemotherapy on hair loss.

Women with PCOS have lower adiponectin hormone levels and are more likely to have insulin resistance.

Hair dyes and perms can damage hair and scalp, but using interventions can reduce harm.

Hidradenitis Suppurativa is a chronic skin condition best treated early with surgery for better outcomes and less recurrence.

A man got six skin cancers within a year after a cell transplant for leukemia but was cancer-free 32 months later; skin checks are important post-transplant.

Essential oils may help hair health but lack strong scientific proof and can cause allergic reactions.

Skin issues can indicate immune system problems.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Rosacea is a skin condition with unclear causes, classified into four subtypes.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Noggin is necessary to start the hair growth phase in skin after birth.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Cathepsin L is essential for normal hair growth and development.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.