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The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.

The Rotterdam Study investigates diseases in older adults and has produced many research findings.

Polycystic ovary syndrome costs the U.S. over $4 billion a year, mainly from treating related health issues.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Dermatologists need to understand hair products to treat hair and scalp issues better.

Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

Testosterone may slow down wound healing and increase inflammation.

Researchers found 71 genetic regions linked to male pattern baldness, which account for 38% of its genetic risk.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.

People with alopecia are at higher risk for heart disease and have more heart-related risk factors.

Macrophages are essential for successful skin growth in reconstructive surgery.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

The current system can't fully test all combination treatments, so alternative methods and regulatory flexibility are needed.

Systemic Lupus Erythematosus has varied symptoms and is hard to diagnose, affecting many body parts and requiring careful clinical judgment.

Women with PCOS have higher xanthine oxidase activity linked to inflammation and heart disease risks.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Skin lymphatic vessels are essential for hair growth.