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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

No treatment fully prevents hair loss from chemotherapy yet.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

BMP2 and BMP7 have opposite roles in feather formation.

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.

Apoptosis is crucial for healthy skin and treating skin diseases.

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

Laser treatment can stimulate hair growth for male pattern hair loss.

TGF-β2 plays a key role in human hair growth and development.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Herbal extracts and platelet-rich plasma together may help increase hair growth by making certain cells grow more, through specific cell growth pathways.

Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.