161 citations
,
August 2013 in “Journal of experimental botany” This study found that specific ATP-competitive TOR inhibitors (asTORis) decrease root growth in Arabidopsis thaliana in a dose-dependent manner, similar to their effects on mammalian cells.
105 citations
,
May 2013 in “Biomaterials” In this study, the researchers found that a keratin hydrogel filler in nerve conduits led to earlier Schwann cell migration and improved cellular behaviors compared to other fillers in a rat sciatic nerve model.
57 citations
,
July 2018 in “Scientific Reports” This study found that prevascularizing dermal matrices with adipose tissue-derived microvascular fragments improved vascularization and allowed earlier successful skin grafting in a bradythrophic wound model.
29 citations
,
April 2020 in “Journal of Tissue Engineering and Regenerative Medicine” This study demonstrates that incorporating human neopapilla into reconstructed human skin can initiate hair follicle morphogenesis by stimulating epidermal invagination and maintaining follicle-inductive properties in vitro.
27 citations
,
May 2016 in “British journal of dermatology/British journal of dermatology, Supplement” 24 citations
,
December 2013 in “Archives of Dermatological Research”
21 citations
,
December 2007 in “Primary Care” This article reviews the challenges in treating PCOS, noting the potential benefits of insulin sensitizers on ovulatory function and pregnancy outcomes, and calls for more long-term studies on metabolic interventions.
17 citations
,
December 2006 in “Gene Expression Patterns” This study reports that the mouse Scube3 gene is expressed in various tissues during embryonic development, including the neural tube, limb buds, developing tooth, hair follicle, and skeletal regions.
13 citations
,
January 2023 in “Annual Review of Cancer Biology” This study suggests that cancer risk may be influenced by the balance of pro- and anti-oncogenic mutants in normal tissues rather than by the total number of mutations.
11 citations
,
April 2013 in “Homo” In this study, 7-10-year-old Polish children showed a significant increase in skin pigmentation levels, with girls exhibiting this change more prominently than boys, suggesting an early sign of puberty.
11 citations
,
January 2009 in “Acta Dermato Venereologica” In this case report, a 37-year-old man with discoid lupus erythematosus experienced around 80% hair regrowth after treatment with a combination of oral and topical therapies.
11 citations
,
April 1990 in “Australasian Journal of Dermatology” This study found that 2% minoxidil solution significantly increased non-vellus hair counts and regrowth rates compared to placebo in men with early androgenic alopecia, suggesting it is an effective treatment.
10 citations
,
May 2014 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that altering neurosteroid levels during early development in male rats can influence KCC2 levels, underscoring the role of neurosteroids in hippocampal maturation.
10 citations
,
April 2009 in “Oncology Reports” This study found distinct skin surface changes, including faint mosaic melanoderma and atypical scaliness, on long-standing sun-exposed balding scalps that may be associated with actinic field carcinogenesis.
7 citations
,
August 2018 in “The American Journal of Dermatopathology” This study describes a newly observed "inflammatory vellus involvement" pattern in early frontal fibrosing alopecia, which may lead to misdiagnosis due to the absence of typical histological features.
5 citations
,
September 2022 in “Frontiers in Nutrition” This review discusses the potential influence of gut microbiota on alopecia areata and suggests fecal microbial transplantation as a possible therapeutic approach but reports no new results.
5 citations
,
January 2017 in “Acta medico-historica Adriatica” This study examines the use of urotherapy in Spanish folk medicine, highlighting its widespread application for treating skin conditions and the cultural symbolism associated with urine-based remedies.
5 citations
,
September 1998 in “Medical hypotheses” This article discusses the potential of using flutamide and finasteride for complete androgen blockade in early-stage, low-grade prostate cancer and suggests they may improve symptom-free and overall survival compared to observation.
4 citations
,
August 2025 in “Scientific Reports” This study found that hair analysis is an effective non-invasive method for assessing metabolic fluctuations, showing stable advanced glycation end products levels that correlate with age and differ significantly between diabetic and non-diabetic rats.
4 citations
,
October 2020 in “Research Square (Research Square)” This study reported that more sensitive, early diagnosis and treatment of COVID-19 with drug combinations significantly improved clinical outcomes in males with or without androgenetic alopecia, preventing severe progression.
3 citations
,
October 2022 in “Frontiers in Cell and Developmental Biology” This review explores the historical development of theories on physiological tissue regeneration, particularly focusing on peripheral nerve regeneration, and emphasizes the need for new experiments and perspectives without providing new empirical findings.
3 citations
,
January 2022 in “Journal of Infection” This article discusses intra-host single-nucleotide variants in SARS-CoV-2, highlighting their potential to inform on virus strain diversity, immune escape, and drug design, but it reports no new clinical results.
2 citations
,
May 2023 in “Anais Brasileiros de Dermatologia”
2 citations
,
November 2020 in “International Journal of Otorhinolaryngology and Head and Neck Surgery” The researchers reported that nasolabial flaps were effective for reconstructing small to intermediate oral cavity defects in early oral cancer patients, with overall good cosmetic and functional outcomes despite some complications.
2 citations
,
December 2013 in “Cancer Research” This study found that scalp cooling did not entirely prevent permanent chemotherapy-induced alopecia in breast cancer patients, with a significant risk observed among postmenopausal women undergoing anthracycline and taxane-based chemotherapy.
1 citations
,
August 2025 in “Frontiers in Bioengineering and Biotechnology” This study found that a 3D wound model, the 3DWoundSE, showed improved responsiveness to injury and cytotoxic stimuli compared to an intact 3D skin equivalent, offering a reproducible and ethical alternative to animal models for early wound response assessment in dermatological research and drug development.
1 citations
,
June 2025 in “Supportive Care in Cancer” This study found that adjuvant docetaxel chemotherapy is linked to higher rates of dissatisfaction and chronic alopecia compared to paclitaxel chemotherapy, suggesting these outcomes should be discussed with patients before using docetaxel regimens.
1 citations
,
November 2022 in “Nutrients” This study found that piglets' rapid growth during nursery and lactation was linked to changes in microbiota composition and increased cortisol conversion, highlighting critical early life factors influencing adult microbiota establishment.
1 citations
,
October 2022 in “Biomedicines” This study found that Prdm1 is crucial for whisker development in mice, affecting multiple signaling pathways and possibly playing a role in primates' evolutionary loss of vibrissae.
1 citations
,
June 2022 in “Journal of Paediatrics and Child Health” This study observed that patients with paediatric-onset chronic hepatobiliary disease face a substantial health-care burden, highlighting challenges in transitioning this diverse group to adult care services.