research Biofabrication of Human Skin with Its Appendages
Current methods can't fully recreate skin and its features, and more research is needed for clinical use.
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research Challenges in Treatment of Patients With Non-Classic Congenital Adrenal Hyperplasia
Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.
research Observations Suggesting a Contribution of Altered Dermal Papilla Mitochondrial Function to Androgenetic Alopecia
Hair loss in men might be linked to changes in cell energy factories.
research GDNF Neurotrophic Factor Signaling Determines the Fate of Dermal Fibroblasts in Wound-Induced Hair Neogenesis and Skin Regeneration
GDNF signaling helps in hair growth and skin healing after a wound.
research Epigenetic Mechanism of Gtl2-miRNAs Causes the Primitive Sheep Characteristics Found in Purebred Merino Sheep
A special gene region controls the re-emergence of a primitive wool type in Merino sheep, improving their wool yield and adaptability.
research The Feasibility and Utility of Hair Follicle Sampling to Measure FMRP and FMR1 mRNA in Children With or Without Fragile X Syndrome: A Pilot Study
Hair follicle sampling is a practical method for measuring biomarkers in children with and without Fragile X syndrome.
research First-In-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.
research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn
Delta opioid receptors help regulate touch sensation by reducing neurotransmitter release in the spinal cord.
research Miz1 Is Required for Hair Follicle Structure and Hair Morphogenesis
Miz1 is essential for proper hair structure and growth.
research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State
Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
research Co-Factors of LIM Domains (Clims/Ldb/Nli) Regulate Corneal Homeostasis and Maintenance of Hair Follicle Stem Cells
Clim proteins are essential for maintaining healthy corneas and hair follicles.
research Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration
Zebrafish need MYC and FGF to regenerate inner ear hair cells.
research Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile
Thymic mesenchymal cells have unique gene expression that supports their specific functions in the thymus.
research Complex X Chromosome Rearrangement Associated with Multiorgan Autoimmunity
A complex X chromosome rearrangement can increase the risk of multiple autoimmune diseases.
research Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation
NIPP1 is important for healthy skin and could help treat skin inflammation.
research A Hairy Situation: PADIs in Regeneration and Alopecia
Enzymes called PADIs play a key role in hair growth and loss.
research Regulation of Stem Cell Fate by HSPGs: Implication in Hair Follicle Cycling
HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.
research A Single-Cell RNA Map of Perinatal Developing Mouse Skin
The research mapped gene activity in developing mouse skin and found key markers for skin cell types and changes from fetal to early postnatal stages.
research Fibroblast Heterogeneity: Implications for Human Disease
Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.
research Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis
Laminin-511 is crucial for early hair growth and maintaining important hair development signals.
research Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo
Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.
research Left Ventricular Myocardial Mass Index and Its Correlates as an Early Marker of Cardiovascular Risk Among Nonobese Normotensive Indian Women With Polycystic Ovary Syndrome: Lessons From a Cross-Sectional Study
Nonobese, normotensive Indian women with PCOS may have a higher risk of heart problems linked to inflammation and insulin resistance.
research Dermal EZH2 Orchestrates Dermal Differentiation and Epidermal Proliferation During Murine Skin Development
Dermal EZH2 controls skin cell development and hair growth in mice.
research Genetic, Hormonal, and Metabolic Aspects of PCOS: An Update
The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.
research Author Response: Lhx2 as a Progenitor-Intrinsic Modulator of Sonic Hedgehog Signaling During Early Retinal Neurogenesis
Lhx2 is a crucial regulator of the Sonic Hedgehog signaling in early mouse retinal development.
research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia
Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
research BAF200 Is Required for Heart Morphogenesis and Coronary Artery Development
BAF200 is essential for proper heart and coronary artery formation.
research Dermal Papilla Cells Induce Keratinocyte Tubulogenesis in Culture
Skin cells can help create early hair-like structures in lab cultures.
research The Pediatric Origins of Polycystic Ovary Syndrome
Early signs of PCOS in girls, like irregular periods and polycystic ovaries, suggest a need for early diagnosis and intervention to prevent further health issues.
research YKL-40: A Sensitive Biomarker for Early Androgenetic Alopecia and Early Hidden Metabolic Syndrome
High YKL-40 levels predict early hair loss and hidden metabolic issues.