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New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

Scientists created hair-growing skin models from stem cells, which could help treat hair loss and skin diseases.

Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

Trichilemmal carcinoma shares genetic changes with other skin cancers, suggesting similar causes and potential treatments.

New treatments like nanotechnology show promise in improving skin cancer therapy.

The HPV type 11 region activates hair-specific gene expression in mice.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

Advancements in nanoformulations for CRISPR-Cas9 genome editing can respond to specific triggers for controlled gene editing, showing promise in treating incurable diseases, but challenges like precision and system design complexity still need to be addressed.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

Eating fewer calories may slow skin aging and improve skin health through various biological changes.

Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.

Lung and liver macrophages protect our tissues and their dysfunction can cause various diseases.

The research showed how melanocytes develop, move, and respond to UV light, and their stem cells' role in hair color and skin cancer risk.

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

Skin cells from people with Epidermolysis Bullosa Simplex have abnormally placed and less active mitochondria.

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

Exosomes could be a promising way to help repair skin and treat skin disorders.

High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

ING5 is crucial for stem cell maintenance and preventing certain cancers.

Dermal papilla cells can help regrow hair and are promising for hair loss treatments.

Vitamin D receptor is crucial for skin wound healing.

Exosomal miRNAs from stem cells can help improve skin health and delay aging.

Sunlight exposure damages hair follicles, but certain stem cell-derived particles can reduce this damage and help with hair regeneration.

Cells lacking the Bax protein can outcompete others, leading to better tissue repair and hair growth.

The calcineurin/NFAT pathway plays a significant role in the development and growth of a type of skin cancer called cutaneous squamous cell carcinoma.

The document concludes that individualized treatment for malignant epithelial tumors is necessary and more research on metastatic squamous cell carcinoma treatments is needed.