June 2026 in “British Journal of Dermatology” This study found that subjective scalp sensations like hurting and burning are common among alopecia patients, with burning in particular showing a significant association with psychological distress in patients with lichen planopilaris and androgenetic alopecia, suggesting a potential psychoneuroinflammatory pathway.
July 2022 in “Dermatology practical & conceptual” This study found that a topical henna formulation may improve symptoms like itching, burning, and redness in patients with recessive dystrophic epidermolysis bullosa, but larger controlled studies are needed.
2 citations
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January 2017 in “Indian Dermatology Online Journal” This case report describes a rare instance of dermographic urticaria triggered by an 810 nm diode laser for hair removal, with symptoms managed effectively by pre-treatment with levocetirizine.
5 citations
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July 1999 in “Journal of Anatomy” This study found that methylene blue staining may reveal anatomical details of intraepidermal nerve fibre endings in the rat mystacial pad with greater clarity than the zinc iodide-osmium tetroxide technique.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that mice lacking epidermal HSD11b1 had increased non-histaminergic itch and changes in skin nerve fibers, potentially linked to higher TSLP expression.
9 citations
,
January 2022 in “Dermatology” This review reports a notably higher prevalence and severity of alexithymia among dermatology patients than healthy controls, suggesting its consideration may enhance treatment outcomes and quality of life.
56 citations
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November 1993 in “Journal of The American Academy of Dermatology” Capsaicin cream quickly relieved itching in two patients with brachioradial pruritus.
114 citations
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March 2002 in “Current opinion in oncology/Current opinion in oncology, with cancerlit” This review discusses various skin side effects from chemotherapy, noting that they are mainly toxic rather than allergic and often include alopecia, which can cause significant distress to patients.
December 2025 in “Molecular Pain” This study identified that the MC-5-HT-HTR2A axis plays a role in chronic pruritus in a mouse model of SADBE-induced allergic contact dermatitis, suggesting potential for therapeutic targeting.
135 citations
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May 2002 in “Anesthesiology” This review examines current knowledge and treatment strategies for complex regional pain syndrome type I in adults, emphasizing clinical aspects and highlighting the lack of consensus on therapeutic approaches, without presenting new clinical findings.
14 citations
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October 2003 in “Annals of Oncology” In this study, the researchers observed that the severity of capecitabine-induced hand-foot syndrome in advanced gastric cancer patients was not linked to the IVS14+1G→A mutation in the DPYD gene.
1 citations
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September 2005 in “Oncology times” In this study, wearing a frozen glove during docetaxel chemotherapy reduced nail problems in patients' gloved hands compared to unprotected hands, with onycholysis absent among protected hands.
November 2025 in “Indian Journal of Dermatology” This study reports a rare cluster of four patients with ectodermal dysplasia, highlighting its typical dental and dermatological manifestations and the necessity of multidisciplinary management.
4 citations
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October 2021 in “Journal of Clinical Medicine” This study found that individuals with heterozygous truncation-type variants in the *DSP* gene exhibit lower skin temperature and higher transepidermal water loss, with specific microscopic skin changes and pseudomonilethrix.
September 2025 in “PubMed” In this study, auricular electrostimulation effectively relieved dextran-induced pruritus in mice, comparable to loratadine treatment, and is attributed to down-regulating the H1R/TRPV1 signaling pathway and reducing inflammatory cells in the skin.
3 citations
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January 2014 in “The Journal of Dermatology” This letter discusses a case of hapten-induced lymphadenosis benigna cutis following sensitization with squaric acid dibutylester for treating alopecia areata and reports no new clinical results.
March 2026 in “Indian Dermatology Online Journal” This report details a case study where a 40-year-old woman experienced allergic contact dermatitis and angioedema-like symptoms after using PPD-containing hair dye. Patch testing confirmed a positive reaction to PPD, highlighting the substance's potential to cause both T-cell and IgE-mediated hypersensitivity reactions.
7 citations
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January 1998 in “PubMed” Hair loss can cause scalp discomfort.
24 citations
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March 2009 in “Journal of the European Academy of Dermatology and Venereology” This paper highlights trichodynia as a distinguishing symptom of telogen effluvium, but it does not present new clinical findings.
11 citations
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January 2017 in “Dermato-endocrinology” This study observed that common skin changes in patients with type 2 diabetes included peripheral hair loss, xerosis, anhydrosis, and nail alterations, underscoring the importance of controlling blood sugar and foot care to prevent neuropathy complications.
6 citations
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January 2015 in “Indian Dermatology Online Journal” This case report describes a unique presentation of porokeratotic eccrine ostial and dermal duct nevus with lesions on the dorsum of the hand and a focal lichenoid infiltrate, differing from typical palm and sole involvement.
October 2021 in “JAAD Case Reports” This article discusses diabetic gustatory hyperhidrosis as a rare form of autonomic dysfunction linked to severe diabetic neuropathy and nephropathy, noting its impact on social and emotional well-being.
5 citations
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July 2020 in “Journal of Cosmetic Dermatology” This study found that using a vibration anesthetic device during scalp mesotherapy significantly reduced pain in patients with androgenetic alopecia and alopecia areata compared to the non-vibration side.
March 2005 in “Journal of The American Academy of Dermatology” This article highlights the lack of research on the prevalence and characteristics of pain and itch in early stages of mild to moderate varicose vein disease, without reporting new findings.
This study found that Dex-loaded hyaluronic acid hydrogel microneedles significantly reduced pain in an acute inflammatory visceral pain model without sedation, suggesting a promising and patient-friendly alternative to intravenous delivery.
April 2016 in “Journal of Investigative Dermatology” This study found that administering botulinum toxin A via Flex-PADs to mouse footpads inhibited sweating similarly to traditional injections, suggesting a promising patient-friendly delivery method for hyperhidrosis treatment.
1 citations
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September 2017 in “BMJ” The man has a disease causing skin patches, thickened nerves, and mild muscle weakness.
11 citations
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July 1999 in “Plastic and Reconstructive Surgery” This study reported successful outcomes in over 40 patients undergoing reparative surgical techniques for previously unsuccessful hair restoration, with significant improvements in appearance despite potential challenges like limited donor hair and scalp scarring.
April 2023 in “Journal of Investigative Dermatology” This study demonstrated that the Epidermal Biopotential Sensing System (EBSS) can measure digital biomarkers of pain in mice, suggesting potential applications in assessing pain and screening analgesics in populations with communication difficulties.
142 citations
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September 2020 in “Journal of neurophysiology” This study estimates that young adults have about 230,000 tactile afferent fibers innervating their skin, with density varying by region and decreasing with age.