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Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

Survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis need ongoing care for various long-term health problems.

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Finasteride may cause slight depression and anxiety.

Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

No treatment fully prevents hair loss from chemotherapy yet.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

Male pattern baldness involves smaller hair follicles, larger oil glands, and other tissue changes, but not major blood supply issues.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Different hair evaluation methods have their own pros and cons, and using multiple methods together is best for accurate hair loss diagnosis and tracking.

The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.