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PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

The research found that Atypical Progeroid Syndrome has unique symptoms and is not caused by the buildup of a certain mutant protein.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Testosterone treatment effectively causes male physical development in transgender male adolescents but may lead to side effects like acne, higher BMI and blood pressure, lower good cholesterol, and decreased bone density.

Improving insulin sensitivity and weight loss can help manage polycystic ovary syndrome (PCOS).

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

PCOS is often linked to insulin resistance and obesity, and weight loss can improve symptoms.

Liraglutide caused significant weight loss in some obese women with PCOS, especially those with severe obesity and insulin resistance.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

ARL15 is important for fat cell development and the release of the hormone adiponectin.

The study concludes that mutations in the AEBP1 gene can cause a form of Ehlers-Danlos syndrome and should be considered in diagnosis.

Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.

The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.

Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.

Men with advanced liver disease and high oestrone and low testosterone levels have worse health outcomes.

The document concludes that low-dose oral contraceptives and hormonal therapies can manage perimenopause symptoms and reduce some health risks, but lifestyle changes and disease screening are also important.

New patents show progress in developing drugs targeting the Wnt pathway for diseases like cancer and hair loss.

Changing the diet of mice lacking the enzyme CBS can affect symptoms related to the genetic condition.

We need better ways to test and understand SARMs to make safer and more effective treatments.

Healthcare providers need better education and resources to give competent and sensitive care to transgender patients.