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HSD11b1 affects skin nerves and increases non-histaminergic itch.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Fisetin, a type of polyphenol, may help hair grow by increasing certain protein activities in cells.

Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.

Finasteride helps treat prostate issues and may prevent prostate cancer in high-risk men.

Improved finasteride formula allows slow, sustained release and better absorption for patients.

Cellulose nanocrystals are promising for making effective, sustainable sensors for various uses.

Scientists successfully purified a protein called Wnt3a, which is involved in processes like hair growth, but the overall yield was low, suggesting more work is needed to improve this.

Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.

Newborn screening and gene therapy are expected to improve outcomes for Omenn syndrome patients.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Low-level Laser Therapy may help reduce inflammation, pain, and aid healing, but more research is needed to confirm its effectiveness and establish standard treatment guidelines.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

New nanofiber technology improves wound healing by supporting cell growth and delivering treatments directly to the wound.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Estrogen therapy can reduce skin aging but has cancer risks.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.