29 citations
,
November 2015 in “Acta Biomaterialia” This study found that water-filtered infrared A radiation can induce the release of a model drug from gold nanoparticle-doped particles in hair follicles in an ex vivo porcine skin model, suggesting feasibility for follicular drug delivery systems.
29 citations
,
March 2014 in “PloS one” In this study, Astragaloside IV was found to inhibit apoptosis-related pathways in hair follicles of mice, suggesting it may serve as an alternative therapy for hair loss.
28 citations
,
December 1997 in “Journal of Biological Chemistry” This study found that the hHa1-t protein variant, caused by a genetic polymorphism in the hHa1 gene, forms functional keratin filaments despite lacking a complete nonhelical tail domain, explaining the absence of a pathological hair phenotype.
27 citations
,
September 2021 in “Microbiology Spectrum” This study found that multimetal starvation by the immune protein calprotectin triggers unique regulatory responses in Pseudomonas aeruginosa, beyond those seen with individual metal shortages.
27 citations
,
April 2008 in “Journal of Biological Chemistry” This study found that simvastatin interfered with insulin-induced VEGF expression and keratinocyte proliferation during skin repair in mice, effects that could be reversed by mevalonate.
26 citations
,
September 2001 in “Journal of Investigative Dermatology” This study found that the serine protease BSSP is strongly expressed in mouse skin during carcinogenesis and is upregulated independently of c-Fos and unaffected by glucocorticoids.
25 citations
,
May 2017 in “InTech eBooks” This review details the diverse catalytic activities of abzymes in systemic lupus erythematosus (SLE) and reports no new experimental findings; it discusses the impact of these abzymes on disease pathogenesis.
25 citations
,
July 2015 in “EMBO Reports” This study suggests that mouse lineage specification during pre-implantation development involves distinct timing and mechanisms for trophectoderm and inner cell mass differentiation, challenging existing models.
24 citations
,
March 2024 in “Small Science” This review discusses the potential applications and advantages of encapsulating single cells for use in therapeutics and diagnostics, while also evaluating various methods for effectively creating and sorting single-cell units despite challenges in production and cost.
24 citations
,
October 2012 in “The International Journal of Biochemistry & Cell Biology” In this study, testosterone protected female embryonic heart cells from metabolic stress by being converted into metabolites that activate estrogen receptors and up-regulate certain mitochondrial channel proteins.
24 citations
,
November 1997 in “Journal of Biological Chemistry” This study found that genes encoding mouse high-glycine/tyrosine proteins show distinct spatial and temporal expression patterns in hair follicles, suggesting diverse protein distribution during hair growth cycles.
23 citations
,
November 2018 in “International Journal of Molecular Sciences” This study found that deoxyshikonin promoted wound healing in diabetic mice, suggesting it may contribute to wound repair in patients with diabetes.
22 citations
,
February 2024 in “Heliyon” This review discusses the potential of fibrinolytic enzymes from various sources, especially fermented foods, for their therapeutic use in cardiovascular diseases and emphasizes the need for further research on those from non-Asian regions to optimize discovery and application.
22 citations
,
August 2020 in “Molecules” This study found that applying AGN root extract containing decursin to mouse skin accelerated hair growth and altered inflammatory cytokine levels compared to a control.
22 citations
,
January 2020 in “PeerJ” This study suggests that keratin peptide signatures in human hair shafts could potentially be used to distinguish gender and ethnicity, though further research on a larger scale is needed.
21 citations
,
March 2023 in “Journal of Crohn s and Colitis” This study suggests that microvascular damage and platelet deregulation may persist in ulcerative colitis patients even during remission, remaining as disease-associated molecular signatures.
21 citations
,
November 2019 in “Molecular & Cellular Proteomics” This study found that citrullinated proteins, which are implicated in rheumatoid arthritis, were abundant in outer membrane vesicles from Porphyromonas gingivalis but nearly absent in mutants, validating their approach to citrullinated peptide identification.
21 citations
,
May 2018 in “Journal of Cosmetic Dermatology” This study found that costunolide promotes hair growth in both lab-cultured human hair follicle cells and in live mice by modulating growth factor pathways.
19 citations
,
May 2022 in “International journal of molecular sciences” This study suggests that PRX01, PRX44, and PRX73 regulate extensin-mediated cell wall properties during root hair cell growth, influencing growth patterns, peroxidase activity, and cell wall thickness.
19 citations
,
January 2012 in “Biomolecules & Therapeutics” This study found that Grateloupia elliptica extract may help treat hair loss by promoting dermal papilla cell proliferation, inhibiting 5α-reductase, and reducing inflammation in various cell types.
19 citations
,
August 2022 in “Forensic Science International Genetics” This study developed and validated tissue-specific and age prediction models using epigenetic markers, achieving up to 83.69% correct classification for tissue origin and a median absolute error of ±3.66 years for age estimation.
18 citations
,
April 2018 in “Biotechniques/BioTechniques” This study developed a method for extracting proteins from micro-sized human head hairs, facilitating proteomic analysis even with limited hair sample availability.
17 citations
,
May 2021 in “Journal of Cell Science” In this study, the researchers discovered that specific polyamine depletion enhances stemness in hair follicle stem cells through a mechanism independent of mRNA translation.
17 citations
,
July 2013 in “Amino Acids” This study found that elevated epidermal ODC activity in transgenic mice promotes skin tumor development by recruiting bulge stem cells, rather than through reactive oxygen species generation by polyamine catabolic oxidases.
16 citations
,
January 2015 in “Forensic science international” This study found that two pre-Hispanic mummies from the Andean coast had well-preserved hair with significant amounts of heavy metals like iron, lead, bromide, and occasionally arsenic, revealing their historical context.
14 citations
,
March 2022 in “Journal of Biomedical Science” In this study, Cyanidin 3-O-arabinoside was found to protect against DHT-induced dermal papilla cell senescence and mitochondrial dysfunction in androgenetic alopecia, restoring hair growth in mouse models.
14 citations
,
November 2012 in “SLAS discovery” This study observed that certain herbal extracts may promote hair growth and inhibit hair loss in cell lines by affecting specific protein expressions similarly to minoxidil.
13 citations
,
October 2016 in “Acta Biochimica et Biophysica Sinica” This study found that GhPLDα1 in upland cotton may be involved in fiber development, correlating with increased hydrogen peroxide and cellulose biosynthesis during secondary cell wall thickening.
13 citations
,
October 2020 in “BMC Genomics” This study revealed specific patterns and potential functions of long non-coding RNAs during the hair follicle cycle of yaks, offering insights into their sequence conservation between yaks and cashmere goats.
12 citations
,
November 2024 in “Plants” This study found that the phytosterols β-sitosterol, stigmasterol, and campesterol have low-to-negligible inhibitory activity against steroidal 5α-reductase type 2 compared to the synthetic inhibitor dutasteride, with β-sitosterol showing the highest activity among the tested phytosterols.