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This study reports the first familial case of alopecia linked to a novel homozygous variant in the DSP gene, which did not coincide with heart abnormalities despite prior associations.

A specific gene variant is linked to heart disease, increased heart muscle, curly hair, and thick skin on palms and soles.

This study found that Platelet Rich Plasma is effective as a direct pulp capping agent, comparable to Mineral Trioxide Aggregate, but with potentially better cellular dentinogenic responses and homogenous tissue formation in dogs.

This study found that Wnt10a expression in odontoblasts increased with dental pulp regeneration and may be a potential non-cellular agent for inducing dental pulp regeneration with dentine-inducing capacity.

This study reports previously unrecognized cellular complexity in growing mouse incisors, suggesting species-specific differences in cell dynamics between mouse and human teeth related to growth and differentiation.

This study identified WNT10A as crucial for adult epithelial cell proliferation and differentiation, suggesting β-catenin pathway activation may help address regenerative defects in WNT10A mutation patients.

This study found that overexpression of the transcription factor NFIC may enhance the proliferation and differentiation of stem cells from the apical papilla, suggesting its potential role in dentin/root regeneration.

This study found that upregulation of NFIC may enhance proliferation and osteogenic/cementogenic differentiation in rat dental follicle cells.

This study reveals that basement membrane composition and structure in mouse hair follicles are specialized for distinct inter-tissue interactions, with laminin α5 being essential for maintaining these interfaces.

This study reported that a colistin sulfate-loaded nanoemulgel showed improved antimicrobial activity and skin permeability compared to a CS solution, suggesting a potential new approach for treating severe infections caused by multidrug-resistant bacteria.

This study found that keratin-75, discovered in enamel tissue, is secreted by ameloblasts using an unconventional pathway involving the ER-Golgi-Intermediate-Compartment and Golgi, differing from typical cytokeratin localization.

This study reports a case of a child with congenital skin fragility, alopecia, and cardiomyopathy due to compound heterozygous mutations in the DSP gene causing desmoplakin deficiency.

This study found that the 15-PGDH inhibitor DPP improved endothelial function in hair-related cells exposed to DHT by reducing oxidative stress and enhancing angiogenic capacity.

This study identified ISPP-Rb, a novel immuno-stimulatory complex from Royoporus badius, that significantly activates murine macrophage cells and induces multiple proinflammatory cytokines.

This study describes a capillary GC method for accurately measuring spermidine levels in hair lotions, confirming its precision and specificity for this application.

This study used single-cell and spatial transcriptomic profiling to identify specific molecular markers in human follicular dermal papilla cells, enhancing understanding of their role in hair follicle development.

In this study, the researchers successfully increased dipicolinic acid production in Bacillus subtilis by genetically modifying the spoVF operon, achieving a significant productivity improvement in the culture medium.

Deep Brain Stimulation helps manage Parkinson's symptoms when medication isn't enough.

This study found that cPPARγ and dnPPARγ isoforms are differentially expressed in healthy human skin, suggesting that PPARγ modulators may have compartment-specific effects depending on isoform presence.

Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.

In this study, the researchers discovered that specific polyamine depletion enhances stemness in hair follicle stem cells through a mechanism independent of mRNA translation.

In this study, 12-Chloracetyl-PPD showed anti-cancer activity by inhibiting cancer cell viability and inducing apoptosis through reactive oxygen species production without harming normal cells.

In this exploratory in vitro study, treatment with spermidine increased cell viability and altered gene expression in human epidermal keratinocytes, suggesting potential benefits to cellular health and function, though effects on mitochondrial markers were not significant.

This report describes the enhancement of the French SNIIRAM/SNDS healthcare database through external data linkages, highlighting its potential use in medical research despite complexities in the integration process.

This study explored the effects of DPP, a 15-PGDH inhibitor, on human follicle dermal papilla cells damaged by dihydrotestosterone and observed that DPP enhanced wound healing, reduced reactive oxygen species, and increased hair growth in ex vivo human hair follicle cultures.

In this study using Xenopus laevis embryos, reduced levels of the desmosomal protein desmoplakin led to defects in epidermal and cardiac structures, suggesting its crucial role in tissue integrity.

This study found that the peptide derivative beta-Ala-Pro-Dab-NHbenzyl may reduce wrinkles and sebum production in human skin by inhibiting dipeptidyl peptidase 4, suggesting potential for acne and skin inflammation treatment.

The care model improved timely diagnosis and treatment for psoriasis and psoriatic arthritis.

This study found that individuals with heterozygous truncation-type variants in the *DSP* gene exhibit lower skin temperature and higher transepidermal water loss, with specific microscopic skin changes and pseudomonilethrix.

This study found that the serine protease BSSP is strongly expressed in mouse skin during carcinogenesis and is upregulated independently of c-Fos and unaffected by glucocorticoids.