January 2021 in “Medical Research Archives” This study observed that 25-hydroxyvitamin D3 restored rickets symptoms in genetically modified rats, suggesting its direct action through vitamin D receptor pathways.
September 2025 in “Clinics and Practice” This study found that six-month supplementation with fish-derived collagen peptides, calcium, and vitamin D3 improved skin hydration and elasticity and reduced hair loss in menopausal women, with collagen playing a dominant role in enhancing skin elasticity.
510 citations
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August 2006 in “Endocrinology” This minireview discusses a proposed model of the vitamin D receptor that explains how 1alpha,25(OH)2D3 can mediate both genomic and rapid responses through different ligand shapes and cellular locations, without presenting new research findings.
139 citations
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February 2014 in “Journal of Advanced Research” This review explores the impact of vitamin D deficiency on the skin from a dermatological perspective, but reports no new clinical results.
98 citations
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February 2010 in “Dermatology Online Journal” This article outlines the potential for upregulating the vitamin D receptor in treating hair disorders, emphasizing the need for further studies to evaluate vitamin D's role in the hair cycle.
82 citations
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April 1981 in “Clinical endocrinology” This study describes a case of vitamin D resistant rickets in a young girl due to end organ unresponsiveness, highlighting a possible new subtype of the disorder with distinct clinical features.
36 citations
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February 2007 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that vitamin D receptor activation in primary keratinocytes can occur independently of the 1,25-dihydroxyvitamin D3 ligand, likely through interaction with retinoid X receptors.
23 citations
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October 2009 in “Gastroenterology” This article reviews the multifaceted roles of vitamin D beyond bone health and notes its potential involvement in reducing risks of certain cancers and autoimmune diseases, but it presents no new clinical results.
20 citations
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November 2008 This chapter discusses the production, metabolism, and mechanism of action of Vitamin D, including its role in calcium and phosphate metabolism and its function in the epidermis and hair follicles, without presenting new research findings.
14 citations
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September 2021 in “Journal of Cosmetic Dermatology” This review discusses vitamin D's role in hair follicle biology and its association with hair loss but reports no conclusive evidence for its effectiveness as a treatment, indicating the need for further studies.
14 citations
,
January 2019 in “PubMed” This review examines the potential roles of vitamin D in the pathogenesis of alopecia areata and suggests that vitamin D analogs like calcipotriol may have therapeutic potential.
13 citations
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April 2019 in “Actas Dermo-Sifiliográficas” This review discusses the relationship between vitamin D and various skin diseases, highlighting recent findings on its role and the importance of assessing and correcting vitamin D levels, but reports no new clinical results.
7 citations
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January 2017 in “Journal of Clinical Biochemistry and Nutrition” This study found that vitamin D was positively associated with serum ferritin levels in Korean women without metabolic syndrome, but this association was not observed in those with metabolic syndrome.
7 citations
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May 1985 in “Archives of dermatology” This review discusses the metabolism of vitamin D in the body, highlighting its conversion to biologically active forms and involvement in calcium regulation, without presenting new clinical findings.
4 citations
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April 2020 in “Journal of Cosmetic Dermatology” This study found that Chinese patients with alopecia areata, female pattern hair loss, and male androgenetic alopecia had significantly lower serum vitamin D levels than healthy individuals.
2 citations
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May 2018 in “Journal of the American Academy of Dermatology” This meta-regression analysis observed a slightly negative but nonsignificant correlation between vitamin D levels and the severity of alopecia areata, suggesting a complex relationship that requires further investigation.
1 citations
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January 2017 in “The Annals of Clinical and Analytical Medicine” In this study, researchers found no significant association between VDR gene polymorphisms and the susceptibility to alopecia areata, suggesting that these genetic variations may not play a role in the disease's development.
1 citations
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March 2015 in “PubMed” This review discusses the role of vitamin D and its receptor in maintaining skin and hair follicle health, but it reports no new clinical findings.
May 2026 in “Jurnal Sehat Indonesia (JUSINDO)” This systematic review found an inverse relationship between vitamin D levels and the severity, extent, and pattern of alopecia areata, suggesting vitamin D deficiency may contribute to or worsen this autoimmune hair loss condition.
April 2026 in “Annals of Medicine” This study observed that serum 25-hydroxyvitamin D deficiency is significantly associated with Alopecia Areata in a North Indian cohort, particularly among urban residents, suggesting that screening for this deficiency could enhance disease management.
February 2026 in “International Journal of Molecular Sciences” This study found that PDLLA filler treatment may help combat age-related hair thinning by reducing oxidative stress and enhancing hair follicle function in both cell and animal models.
January 2026 in “Nutrients” This study observed that while low vitamin D levels are associated with increased risk of autoimmune thyroid diseases, evidence from clinical trials on vitamin D supplementation shows inconsistent effects on thyroid function and disease progression, underscoring the need for further research.
In this study, PDLLA treatment in middle-aged mice was observed to enhance hair growth by increasing macrophage M2 polarization and hair follicle stem cell proliferation, potentially rejuvenating the skin's microenvironment and offering a novel approach for age-related hair loss.
November 2025 in “Khalij-Libya Journal of Dental and Medical Research” In this study, Libyan patients with diffuse hair loss were found to have significantly lower levels of zinc, ferritin, and vitamin D compared to those without hair loss, suggesting a possible link between these micronutrient deficiencies and hair loss.
October 2025 in “Medical Journal of Babylon” In this study, researchers found that female COVID-19 patients experiencing hair loss had higher testosterone levels and lower Vitamin D levels than healthy controls, suggesting these hormonal factors may play a role in post-COVID-19 hair loss.
March 2025 in “Institutional Repositories DataBase (IRDB)” The testes significantly contribute to vitamin D metabolism and may affect male reproductive health and conditions like hair loss.
January 2025 in “Egyptian Journal of Dermatology and Venerology” This study found that COVID-19 vaccination initially lowered vitamin D levels in serum and hair but increased serum levels after the second dose, except for the Pfizer group. Hair vitamin D showed a nonsignificant increase, and hair loss was most common with the AstraZeneca vaccine.
January 2025 in “Indian Journal of Paediatric Dermatology” This study found no significant difference in serum Vitamin D levels between children with alopecia areata and healthy controls, nor was there any correlation between Vitamin D levels and the severity, duration, or pattern of the condition, or nail changes.
October 2024 in “Frontiers in Nutrition” This study found that patients with alopecia, particularly alopecia areata and female pattern hair loss, often have vitamin D deficiency, suggesting that screening for vitamin D could benefit these patients.
August 2024 in “IAHS Medical Journal” This study, conducted among 50 women with female-pattern hair loss, observed that 89% had deficient or insufficient vitamin D levels and also showed low ferritin levels, suggesting these deficiencies may contribute to hair loss.