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Minoxidil's absorption is too variable for it to be a reliable reference drug.

Ethosomes can safely and effectively deliver various drugs deep into the skin.

The conclusion is that accurately replicating the complexity of the extracellular matrix in the lab is crucial for creating realistic human tissue models.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

People often struggle to consistently use contraceptives and other medications, and long-acting options might be better for those who want to avoid daily doses.

The new hair loss treatment combining nitric oxide and minoxidil in a special carrier is effective for hair regrowth.

Ethosomes improve drug delivery through the skin but may have side effects like irritation.

Minoxidil lowers blood pressure effectively but may cause unwanted hair growth and other side effects.

Minoxidil can be effectively encapsulated in coated nanovesicles for potential drug delivery.

Platinum nanozyme microneedles can effectively and safely promote hair growth for androgenetic alopecia.

Fesoterodine is effective and safe for elderly patients with overactive bladder.

Ethosomes are a promising method for treating hair loss by delivering drugs directly to the scalp.

Future work on macrolide antibiotic analysis will aim to enhance selectivity, sensitivity, and efficiency using advanced chromatographic methods.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Acne vulgaris is a common skin condition that can cause low self-esteem and depression, and early treatment is important to prevent scarring.

Caffeine is beneficial for skin and hair treatments but needs better delivery methods to penetrate deeper skin layers.

The transfollicular route shows promise for noninvasive, targeted drug delivery but needs more research.

Extended-release valproate effectively reduced seizures and improved quality of life in epilepsy patients over 6 months, with some side effects.

Colchicine can inhibit hair growth by affecting cell activity and protein expression in hair follicles.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Switching to extended-release divalproex sodium improved patient-reported tremor but did not change seizure frequency or most side effects.

Minoxidil mixed with β-cyclodextrin improves solubility and gradual release.

Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.

Cepharanthine, a Japanese hair loss drug, shows promise as a COVID-19 treatment but needs more testing.

Drug repurposing speeds up development, cuts costs, and uses known safe drugs, but faces challenges like regulations and patents.

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Particles around 100 nm can penetrate and stay in hair follicles without passing through healthy skin, making them safe for use in topical products and useful for targeted drug delivery.

A blood pressure drug, diltiazem, may also help treat influenza.