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This study found that cedrol-loaded dissolvable microneedles efficiently delivered cedrol to the deep dermis, effectively promoting hair growth in C57BL/6 mice, suggesting a promising strategy for treating hair loss.

CUR-loaded micelles improve skin delivery and effects of curcumin for pain and infections.

This source reviews recent data on topical minoxidil, evaluating its pharmacology, mechanism of action, clinical effectiveness, and side effects in treating hair loss, although its precise mode of action remains unclear.

This study found that a novel effervescent formulation significantly increased minoxidil sulphate accumulation in hair follicles and skin compared to a standard minoxidil solution.

This article outlines how nanotechnology strategies, including phospholipid-based nanocarriers like liposomes, could enhance the effectiveness and skin tolerability of acne treatments, aiming to reduce side effects and improve patient compliance in managing acne vulgaris.

In this study, brief ultrasound exposure reduced the follicular contribution to hydrocortisone absorption while significantly increasing total skin permeability, likely due to removal of the upper stratum corneum.

This study reviewed existing methods to prevent chemotherapy-induced hair loss, highlighting FDA-approved scalp cooling as currently the most effective yet still insufficient solution and noting the need for more reliable treatments to better support cancer patients.

This study focused on developing a nanoemulsion-based gel for delivering minoxidil, aiming to enhance its contact time with the scalp and potentially improve skin absorption compared to conventional topical solutions.

This review highlights recent developments in nanovesicular carriers for enhancing molecule delivery into and across the skin, focusing on the design and evolution of phospholipid and non-phospholipid systems used in cosmetics and treating various skin conditions.

This study suggests that a nanostructured lipid carrier formulation delivering minoxidil and latanoprost may enhance effectiveness and tolerability in treating alopecia by targeting hair follicles.

In this study, a validated chromatographic method demonstrated the ability to simultaneously analyze gemcitabine and olaparib in pancreatic cancer tissues, supporting the advancement of pharmaceutical formulations combining these drugs, particularly for patients with BRCA mutations.

The nanoemulsion system effectively delivers drugs through the skin and shows promise for treating skin conditions.

This study reported that in animal studies of androgenetic alopecia, a biodegradable microneedle patch releasing glutamic acid promoted hair regeneration more effectively than daily minoxidil, with higher hair follicle counts and less frequent dosing, showing the potential for clinical application.

This study developed two types of polymeric nanoparticles containing clindamycin phosphate for potential topical acne treatment and found that the NP-AH-CDM-4 formulation preferentially penetrated hair follicles even with sebaceous obstruction, suggesting its promise for more effective acne therapy without causing skin irritation.

This study reported that squarticles, nanoparticle carriers made from sebum-derived lipids, significantly enhanced minoxidil delivery to hair follicles in vitro, increasing follicular uptake sevenfold and minimizing systemic absorption compared to a free control solution, while showing good skin tolerability.

In this study, researchers developed a dissolvable microneedle patch combining HA-TEMPO and Portulaca oleracea L.-derived nanoparticles, which effectively reduced oxidative stress and inflammation in an atopic dermatitis model while restoring immune balance, suggesting a promising treatment strategy.

This study found that a microneedle system delivering VEGF and Ritlecitinib improved hair regeneration in mice with androgenetic alopecia, showing faster anagen onset and better hair quality compared to minoxidil.

This chapter reviews nanocarriers for acne therapy, highlighting their ability to reduce lesions and inflammation while improving the safety and effectiveness of treatment, though no new clinical results are reported.

Topical finasteride is promising for hair loss with minimal side effects but needs more research and approval.

This review discusses the progress in research on topical formulations for treating alopecia, highlighting potential advantages of advanced formulation technologies but reporting no new clinical results.

This study found that dual-frequency ultrasound with microbubble cavitation significantly enhanced minoxidil delivery and hair growth in both lab and animal models compared to single-frequency ultrasound, without damaging the skin in mice.

This review discusses the use of lipid nanoparticles for topical and transdermal delivery of pharmaceuticals and cosmeceuticals and reports no new clinical results.

This study found that radiofrequency microneedling significantly enhanced the absorption of topical triamcinolone acetonide, with insertion depth being more influential than RF energy levels.

This review highlights that castor oil has potential dermatological uses, including enhancing hair luster, reducing hyperpigmentation, and improving skin hydration and elasticity, although rare side effects like contact dermatitis occur, necessitating further research to confirm its effectiveness in these applications.

This review outlines advances in topical PROTACs for localized protein degradation, focusing on AH-001 and GT20029 for skin conditions, but presents no new clinical trial results.

This review discusses the role of nanocarrier systems, such as nanoemulsions and liposomes, in delivering antioxidants into the skin to counteract oxidative stress, highlighting recent advancements in topical antioxidant therapy through nanotechnology.

This review highlighted the potential of silver nanoparticles' antibacterial properties across biomedical, pharmaceutical, and dental applications, and emphasized plant-based biosynthesis methods as eco-friendly alternatives to conventional nanoparticle production despite existing toxicity concerns.

This study reviews lipid-based nanocosmeceuticals and reports that they enhance therapeutic effectiveness in dermatological applications by improving skin hydration, reducing wrinkles, and effectively managing conditions like psoriasis and eczema, though further large-scale trials and regulatory alignment are needed for clinical use.

In this study, black cumin oil-based nanostructured lipid carriers enhanced the delivery and effectiveness of fluticasone for psoriasis in a mouse model, improving skin targeting, inflammation reduction, and permeability compared to standard cream.

This study described a novel three-dimensional-printed microneedle system designed for improved transdermal delivery of minoxidil to treat hair loss, demonstrating effective hair regrowth and safety in a mouse model while allowing sustainable needle base recovery.