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Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

Different small areas within hair follicles send specific signals that control what type of cells stem cells become.

Different types of stem cells help maintain and heal skin.

Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.

The document concludes that various signaling pathways and genetic factors are crucial for chicken feather development, affecting poultry quality.

HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.

WNT signaling is crucial for skin development and healing.

New tools show that in fish, NPY increases feeding and somatostatin decreases it.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

Activating TRPMLs helps human cells important for hair growth and increases hair growth in mice.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

TLR4 is important in aging-related diseases and could be a new treatment target.

Intravital imaging helps us better understand stem cells in their natural environment and could improve knowledge of organ regeneration and cancer development.

Eyelid cells share signaling components but differ in pathway activity.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

Paneth cells and intestinal stem cells work together metabolically for stem cell function and regeneration.

Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.

The conclusion is that grasping how cells determine their roles through evolution is key, with expected progress from new research models and genome editing.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

New methods have greatly improved our understanding of stem cell behavior and roles in the body.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.