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This article reviews the definitions, opportunities, advantages, and limitations of dental pulp stem cells and stem cells from human exfoliated deciduous teeth in tissue engineering and regenerative medicine, reporting no new clinical results.

This study found that overexpression of Wnt1a in bone marrow mesenchymal stem cells enhanced mouse hair follicle regeneration and promoted hair cycling.

This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.

This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.

This study found that topical administration of the TGFβ mimetic peptide DPS-1 stimulated hair growth in mice by promoting HDP cell proliferation and enhancing hair follicle morphology.

This study developed a new human hair research model combining 3D spheroid dermal papilla fibroblasts with plucked anagen hair shafts, potentially improving the evaluation of hair follicle differentiation.

This review discusses how dental pulp stem cells and their derivatives may accelerate skin wound healing by modulating inflammation, promoting angiogenesis, optimizing extracellular matrix structure, and enhancing tissue formation, with implications for translating these findings into therapies for skin and mucosal repair.

This study found that biomimetic dermal papilla spheres cultured in a specific microenvironment can partially restore hair-inducing ability in high-passage dermal papilla cells in nude mice, resembling the characteristics of primary cells.

This study observed that incorporating human follicle dermal papilla cells into fibrin microgels increased cell viability and the formation of hair follicle structures in in vitro skin cultures compared to traditional dermal papilla spheroids, suggesting a promising approach for hair follicle regeneration therapies.

This study reports that incorporating Lef-1 transfected dermal papilla cells into human skin equivalents significantly promoted hair follicle differentiation and hair fiber growth, offering a potential advancement for managing skin loss.

This study found that microencapsulated dermal papilla cells implanted into mice ears led to the successful regeneration of hair follicles, with APA microencapsulations of 400µm diameter allowing effective nutrient exchange.

This study found that exosomes derived from dental pulp mesenchymal stem cells (DPSC-Exos) significantly promoted hair regrowth and follicle density in a mouse model of androgenetic alopecia, showing similar efficacy to minoxidil by activating pathways that improve follicular vascularization and dermal papilla cell function.

This study found that conditioned medium from human dental pulp stem cells (particularly under hypoxic conditions) improved keratinocyte survival and hair regrowth in a chemotherapy-induced alopecia mouse model and did not promote tumor growth, suggesting potential for safe therapeutic use.

This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.

This article provides contact information for Bruce A. Morgan and features no new research findings.

This study explores how chromatin differences between dermal papilla cells and papillary fibroblasts contribute to hair follicle inductivity and investigates the regulatory changes in androgenic alopecia.

This study found that Wnt1a overexpression from bone marrow mesenchymal stem cells enhanced hair follicle regeneration in mice by promoting the dermal papilla's role in hair cycling and gene expression recovery.

This study found that decreased TRPS1 expression in balding dermal papilla cells may impair their signaling ability, contributing to hair follicle miniaturization in androgenic alopecia.

This review article explores the potential of various mesenchymal stem cell populations derived from oral tissues, such as DPSCs and hPCy-MSCs, in bone tissue engineering and regeneration, detailing their high plasticity and clinical applications in dental procedures.

This study found that dracorhodin perchlorate improved wound healing in diabetic rats by regulating the TLR4 pathway and related inflammatory factors.

In this study, researchers used two dermal papilla spheroid models to investigate hair cycle regression mechanisms and found that the vascular system enhances tissue physiology and gene modulation, while Retinol-based treatments can partially recover tissue degeneration observed over an extended culture period.

In this case report, a 60-year-old man with dermatosis pustular subkorneal showed improvement following treatment with systemic and topical corticosteroids over 4–5 weeks, as diagnosed through clinical and histopathological assessments.

This study developed an in vitro 3D organoid model using dermal papilla spheroids and found that it enhances growth factor expression and extracellular matrix production, which could aid drug screening for hair regeneration.

This study found that STAT5 activation in the dermal papilla acts as a key switch to trigger anagen entry in postdevelopmental hair follicle cycling.

In this study, researchers developed gellan gum hydrogels functionalized with biomimetic peptides that create a supportive microenvironment for human dermal papilla cells, enhancing their hair-inductive capacity and ability to mimic hair morphogenesis-like events in vitro.

This study found that combining human dermal papilla fibroblasts with hair matrix cells formed organoids capable of limited hair follicle development in ex vivo skin, but not fully formed hair follicles.

This study observed that human primary adult hair matrix keratinocytes may have the potential to generate hair follicle organoids, suggesting possible applications in hair follicle neogenesis and preclinical hair growth agent screening.

This study found that microencapsulated dermal papillae cells induced hair follicle regeneration in rat ears, differing from normal follicles in configuration, size, number, and differentiation degree.

In this study, researchers found that the gene LRRC15 was overexpressed in dermal papilla cells from balding areas compared to non-balding areas in patients with androgenetic alopecia.

This study used single-cell and spatial transcriptomic profiling to identify specific molecular markers in human follicular dermal papilla cells, enhancing understanding of their role in hair follicle development.